Deferoxamine modulates cytokines and growth factors to accelerate cutaneous wound healing in diabetic rats

Deferoxamine has shown cutaneous wound healing potential by increased neovascularization. We hypothesized that topically applied deferoxamine facilitates wound healing in diabetic rats by modulating important cytokines and growth factors that take part in healing processes in a time-dependent manner...

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Veröffentlicht in:	European journal of pharmacology 2015-10, Vol.764, p.9-21
Hauptverfasser:	Ram, Mahendra, Singh, Vishakha, Kumawat, Sanjay, Kumar, Dhirendra, Lingaraju, Madhu C., Uttam Singh, Thakur, Rahal, Anu, Kumar Tandan, Surendra, Kumar, Dinesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cytokines Cytokines - genetics Cytokines - metabolism Deferoxamine Deferoxamine - pharmacology Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetic rats Gene Expression Regulation - drug effects Growth factors Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - pharmacology Male Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Skin - drug effects Skin - physiopathology Wound healing Wound Healing - drug effects
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