Multiparametric MRI With Dynamic Contrast Enhancement, Diffusion-Weighted Imaging, and 31-Phosphorus Spectroscopy at 7 T for Characterization of Breast Cancer
OBJECTIVESTo describe and to correlate tumor characteristics on multiparametric 7 tesla (T) breast magnetic resonance imaging (MRI) with prognostic characteristics from postoperative histopathology in patients with breast cancer. MATERIALS AND METHODSInstitutional review board approval and written i...
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Veröffentlicht in: | Investigative radiology 2015-11, Vol.50 (11), p.766-771 |
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creator | Schmitz, Alexander M.Th Veldhuis, Wouter B Menke-Pluijmers, Marian B.E van der Kemp, Wybe J.M van der Velden, Tijl A Kock, Marc C.J.M Westenend, Pieter J Klomp, Dennis W.J Gilhuijs, Kenneth G.A |
description | OBJECTIVESTo describe and to correlate tumor characteristics on multiparametric 7 tesla (T) breast magnetic resonance imaging (MRI) with prognostic characteristics from postoperative histopathology in patients with breast cancer.
MATERIALS AND METHODSInstitutional review board approval and written informed consent of 15 women (46–70 years) with 17 malignant lesions were obtained. In this prospective study (March 2013 to March 2014), women were preoperatively scanned using dynamic contrast-enhanced MRI, diffusion-weighted imaging, and 31-phosphorus spectroscopy (P-MRS). The value of the protocol was assessed to quantify tumor differentiation and proliferation. Dynamic contrast-enhanced MRI was assessed according to the American College of Radiology Breast Imaging Reporting and Data System-MRI lexicon. Apparent diffusion coefficients (ADCs) were calculated from diffusion-weighted imaging. On P-MRS, at the location of the tumor, the amount of phosphorus components was obtained in a localized spectrum. In this spectrum, the height of phosphodiester (PDE) and phosphomonoester (PME) peaks was assessed to serve as a measure for metabolic activity, stratifying tumors into a PDE > PME, PDE = PME, or PDE < PME group. Tumor grade and mitotic count from resection specimen were compared with the MRI characteristics using explorative analyses.
RESULTSOn dynamic contrast-enhanced MRI, the mean tumor size was 24 mm (range, 6–55 mm). An inverse trend was seen between ADC and tumor grade (P = 0.083), with mean ADC of 867 × 10 mm/s for grade 1 (N = 4), 751 × 10 mm/s for grade 2 (N = 6), and 659 × 10 mm/s for grade 3 (N = 2) tumors. Between P-MR spectra and mitotic count, a relative increase of PME over PDE showed significant association with increasing mitotic counts (P = 0.02); a mean mitotic count of 6 was found in the PDE greater than PME group (N = 7), 8 in the PDE = PME group (N = 1), and 17 in the PDE < PME group (N = 3).
CONCLUSIONSMultiparametric 7 T breast MRI is feasible in clinical setting and shows association between ADC and tumor grade, and between P-MRS and mitotic count. |
doi_str_mv | 10.1097/RLI.0000000000000183 |
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MATERIALS AND METHODSInstitutional review board approval and written informed consent of 15 women (46–70 years) with 17 malignant lesions were obtained. In this prospective study (March 2013 to March 2014), women were preoperatively scanned using dynamic contrast-enhanced MRI, diffusion-weighted imaging, and 31-phosphorus spectroscopy (P-MRS). The value of the protocol was assessed to quantify tumor differentiation and proliferation. Dynamic contrast-enhanced MRI was assessed according to the American College of Radiology Breast Imaging Reporting and Data System-MRI lexicon. Apparent diffusion coefficients (ADCs) were calculated from diffusion-weighted imaging. On P-MRS, at the location of the tumor, the amount of phosphorus components was obtained in a localized spectrum. In this spectrum, the height of phosphodiester (PDE) and phosphomonoester (PME) peaks was assessed to serve as a measure for metabolic activity, stratifying tumors into a PDE > PME, PDE = PME, or PDE < PME group. Tumor grade and mitotic count from resection specimen were compared with the MRI characteristics using explorative analyses.
RESULTSOn dynamic contrast-enhanced MRI, the mean tumor size was 24 mm (range, 6–55 mm). An inverse trend was seen between ADC and tumor grade (P = 0.083), with mean ADC of 867 × 10 mm/s for grade 1 (N = 4), 751 × 10 mm/s for grade 2 (N = 6), and 659 × 10 mm/s for grade 3 (N = 2) tumors. Between P-MR spectra and mitotic count, a relative increase of PME over PDE showed significant association with increasing mitotic counts (P = 0.02); a mean mitotic count of 6 was found in the PDE greater than PME group (N = 7), 8 in the PDE = PME group (N = 1), and 17 in the PDE < PME group (N = 3).
CONCLUSIONSMultiparametric 7 T breast MRI is feasible in clinical setting and shows association between ADC and tumor grade, and between P-MRS and mitotic count.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/RLI.0000000000000183</identifier><identifier>PMID: 26135017</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Aged ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - diagnosis ; Breast Neoplasms - metabolism ; Contrast Media ; Diffusion Magnetic Resonance Imaging - methods ; Feasibility Studies ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Magnetic Resonance Spectroscopy - methods ; Middle Aged ; Multimodal Imaging - methods ; Phosphorus Compounds - metabolism ; Phosphorus Isotopes - pharmacokinetics ; Radiopharmaceuticals - pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Investigative radiology, 2015-11, Vol.50 (11), p.766-771</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3563-f1662cd5f5321900ed294e7b0c5ac60cbf169e4ad100722315a99b3c55c959cd3</citedby><cites>FETCH-LOGICAL-c3563-f1662cd5f5321900ed294e7b0c5ac60cbf169e4ad100722315a99b3c55c959cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26135017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitz, Alexander M.Th</creatorcontrib><creatorcontrib>Veldhuis, Wouter B</creatorcontrib><creatorcontrib>Menke-Pluijmers, Marian B.E</creatorcontrib><creatorcontrib>van der Kemp, Wybe J.M</creatorcontrib><creatorcontrib>van der Velden, Tijl A</creatorcontrib><creatorcontrib>Kock, Marc C.J.M</creatorcontrib><creatorcontrib>Westenend, Pieter J</creatorcontrib><creatorcontrib>Klomp, Dennis W.J</creatorcontrib><creatorcontrib>Gilhuijs, Kenneth G.A</creatorcontrib><title>Multiparametric MRI With Dynamic Contrast Enhancement, Diffusion-Weighted Imaging, and 31-Phosphorus Spectroscopy at 7 T for Characterization of Breast Cancer</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>OBJECTIVESTo describe and to correlate tumor characteristics on multiparametric 7 tesla (T) breast magnetic resonance imaging (MRI) with prognostic characteristics from postoperative histopathology in patients with breast cancer.
MATERIALS AND METHODSInstitutional review board approval and written informed consent of 15 women (46–70 years) with 17 malignant lesions were obtained. In this prospective study (March 2013 to March 2014), women were preoperatively scanned using dynamic contrast-enhanced MRI, diffusion-weighted imaging, and 31-phosphorus spectroscopy (P-MRS). The value of the protocol was assessed to quantify tumor differentiation and proliferation. Dynamic contrast-enhanced MRI was assessed according to the American College of Radiology Breast Imaging Reporting and Data System-MRI lexicon. Apparent diffusion coefficients (ADCs) were calculated from diffusion-weighted imaging. On P-MRS, at the location of the tumor, the amount of phosphorus components was obtained in a localized spectrum. In this spectrum, the height of phosphodiester (PDE) and phosphomonoester (PME) peaks was assessed to serve as a measure for metabolic activity, stratifying tumors into a PDE > PME, PDE = PME, or PDE < PME group. Tumor grade and mitotic count from resection specimen were compared with the MRI characteristics using explorative analyses.
RESULTSOn dynamic contrast-enhanced MRI, the mean tumor size was 24 mm (range, 6–55 mm). An inverse trend was seen between ADC and tumor grade (P = 0.083), with mean ADC of 867 × 10 mm/s for grade 1 (N = 4), 751 × 10 mm/s for grade 2 (N = 6), and 659 × 10 mm/s for grade 3 (N = 2) tumors. Between P-MR spectra and mitotic count, a relative increase of PME over PDE showed significant association with increasing mitotic counts (P = 0.02); a mean mitotic count of 6 was found in the PDE greater than PME group (N = 7), 8 in the PDE = PME group (N = 1), and 17 in the PDE < PME group (N = 3).
CONCLUSIONSMultiparametric 7 T breast MRI is feasible in clinical setting and shows association between ADC and tumor grade, and between P-MRS and mitotic count.</description><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Contrast Media</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Middle Aged</subject><subject>Multimodal Imaging - methods</subject><subject>Phosphorus Compounds - metabolism</subject><subject>Phosphorus Isotopes - pharmacokinetics</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1O3DAQha2qqGyBN6gqX_aCgH_iZH3ZBtqutAjEj7iMvM5k4zaxg-0IbR-GZ61XCxXqBXMz0uibczRzEPpEyQklsjy9Xi5OyOuic_4OzajgRUYYJe_RjBBGMillsY8-hvArMawk_APaZwXlgtByhp4upj6aUXk1QPRG44vrBb43scNnG6uGNKicjV6FiM9tp6yGAWw8xmembadgnM3uway7CA1eDGpt7PoYK9tgTrOrzoWxc34K-GYEHb0L2o0brCIu8S1uncdVl4x1BG_-qJjEsGvxNw9bt2rr5Q_RXqv6AEfP_QDdfT-_rX5my8sfi-rrMtNcFDxraVEw3YhWcEYlIdAwmUO5IlooXRC9SoCEXDWUkJIxToWScsW1EFoKqRt-gL7sdEfvHiYIsR5M0ND3yoKbQk1LRnk-5zxPaL5DdTooeGjr0ZtB-U1NSb1Npk7J1P8nk9Y-PztMqwGaf0svUSRgvgMeXZ8-En730yP4ugPVx-5t7b_QjJsg</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Schmitz, Alexander M.Th</creator><creator>Veldhuis, Wouter B</creator><creator>Menke-Pluijmers, Marian B.E</creator><creator>van der Kemp, Wybe J.M</creator><creator>van der Velden, Tijl A</creator><creator>Kock, Marc C.J.M</creator><creator>Westenend, Pieter J</creator><creator>Klomp, Dennis W.J</creator><creator>Gilhuijs, Kenneth G.A</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Multiparametric MRI With Dynamic Contrast Enhancement, Diffusion-Weighted Imaging, and 31-Phosphorus Spectroscopy at 7 T for Characterization of Breast Cancer</title><author>Schmitz, Alexander M.Th ; Veldhuis, Wouter B ; Menke-Pluijmers, Marian B.E ; van der Kemp, Wybe J.M ; van der Velden, Tijl A ; Kock, Marc C.J.M ; Westenend, Pieter J ; Klomp, Dennis W.J ; Gilhuijs, Kenneth G.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3563-f1662cd5f5321900ed294e7b0c5ac60cbf169e4ad100722315a99b3c55c959cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - metabolism</topic><topic>Contrast Media</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Middle Aged</topic><topic>Multimodal Imaging - methods</topic><topic>Phosphorus Compounds - metabolism</topic><topic>Phosphorus Isotopes - pharmacokinetics</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitz, Alexander M.Th</creatorcontrib><creatorcontrib>Veldhuis, Wouter B</creatorcontrib><creatorcontrib>Menke-Pluijmers, Marian B.E</creatorcontrib><creatorcontrib>van der Kemp, Wybe J.M</creatorcontrib><creatorcontrib>van der Velden, Tijl A</creatorcontrib><creatorcontrib>Kock, Marc C.J.M</creatorcontrib><creatorcontrib>Westenend, Pieter J</creatorcontrib><creatorcontrib>Klomp, Dennis W.J</creatorcontrib><creatorcontrib>Gilhuijs, Kenneth G.A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitz, Alexander M.Th</au><au>Veldhuis, Wouter B</au><au>Menke-Pluijmers, Marian B.E</au><au>van der Kemp, Wybe J.M</au><au>van der Velden, Tijl A</au><au>Kock, Marc C.J.M</au><au>Westenend, Pieter J</au><au>Klomp, Dennis W.J</au><au>Gilhuijs, Kenneth G.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiparametric MRI With Dynamic Contrast Enhancement, Diffusion-Weighted Imaging, and 31-Phosphorus Spectroscopy at 7 T for Characterization of Breast Cancer</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>50</volume><issue>11</issue><spage>766</spage><epage>771</epage><pages>766-771</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>OBJECTIVESTo describe and to correlate tumor characteristics on multiparametric 7 tesla (T) breast magnetic resonance imaging (MRI) with prognostic characteristics from postoperative histopathology in patients with breast cancer.
MATERIALS AND METHODSInstitutional review board approval and written informed consent of 15 women (46–70 years) with 17 malignant lesions were obtained. In this prospective study (March 2013 to March 2014), women were preoperatively scanned using dynamic contrast-enhanced MRI, diffusion-weighted imaging, and 31-phosphorus spectroscopy (P-MRS). The value of the protocol was assessed to quantify tumor differentiation and proliferation. Dynamic contrast-enhanced MRI was assessed according to the American College of Radiology Breast Imaging Reporting and Data System-MRI lexicon. Apparent diffusion coefficients (ADCs) were calculated from diffusion-weighted imaging. On P-MRS, at the location of the tumor, the amount of phosphorus components was obtained in a localized spectrum. In this spectrum, the height of phosphodiester (PDE) and phosphomonoester (PME) peaks was assessed to serve as a measure for metabolic activity, stratifying tumors into a PDE > PME, PDE = PME, or PDE < PME group. Tumor grade and mitotic count from resection specimen were compared with the MRI characteristics using explorative analyses.
RESULTSOn dynamic contrast-enhanced MRI, the mean tumor size was 24 mm (range, 6–55 mm). An inverse trend was seen between ADC and tumor grade (P = 0.083), with mean ADC of 867 × 10 mm/s for grade 1 (N = 4), 751 × 10 mm/s for grade 2 (N = 6), and 659 × 10 mm/s for grade 3 (N = 2) tumors. Between P-MR spectra and mitotic count, a relative increase of PME over PDE showed significant association with increasing mitotic counts (P = 0.02); a mean mitotic count of 6 was found in the PDE greater than PME group (N = 7), 8 in the PDE = PME group (N = 1), and 17 in the PDE < PME group (N = 3).
CONCLUSIONSMultiparametric 7 T breast MRI is feasible in clinical setting and shows association between ADC and tumor grade, and between P-MRS and mitotic count.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26135017</pmid><doi>10.1097/RLI.0000000000000183</doi><tpages>6</tpages></addata></record> |
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subjects | Aged Biomarkers, Tumor - metabolism Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Contrast Media Diffusion Magnetic Resonance Imaging - methods Feasibility Studies Female Humans Image Interpretation, Computer-Assisted - methods Magnetic Resonance Spectroscopy - methods Middle Aged Multimodal Imaging - methods Phosphorus Compounds - metabolism Phosphorus Isotopes - pharmacokinetics Radiopharmaceuticals - pharmacokinetics Reproducibility of Results Sensitivity and Specificity |
title | Multiparametric MRI With Dynamic Contrast Enhancement, Diffusion-Weighted Imaging, and 31-Phosphorus Spectroscopy at 7 T for Characterization of Breast Cancer |
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