The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake

The essential oxidoreductase Mia40/CHCHD4 mediates disulfide bond formation and protein folding in the mitochondrial intermembrane space. Here, we investigated the interactome of Mia40 thereby revealing links between thiol-oxidation and apoptosis, energy metabolism, and Ca(2+) signaling. Among the i...

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Veröffentlicht in:	Cell metabolism 2015-10, Vol.22 (4), p.721-733
Hauptverfasser:	Petrungaro, Carmelina, Zimmermann, Katharina M, Küttner, Victoria, Fischer, Manuel, Dengjel, Jörn, Bogeski, Ivan, Riemer, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium Channels - chemistry Calcium Channels - metabolism Calcium-Binding Proteins - antagonists & inhibitors Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cation Transport Proteins - antagonists & inhibitors Cation Transport Proteins - chemistry Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Dimerization Disulfides - chemistry Disulfides - metabolism HEK293 Cells HeLa Cells Humans Ions - chemistry Ions - metabolism Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - antagonists & inhibitors Mitochondrial Membrane Transport Proteins - chemistry Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism RNA Interference RNA, Small Interfering - metabolism
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