CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator)

Uroporphyrin (URO) accumulation in the liver of animals treated with polyhalogenated aromatic hydrocarbons (PHAH) is associated with increased microsomal oxidation of uroporphyrinogen catalyzed by rodent CYP1A2 and by a similar form in chicken, CYP1A5. The planar biphenyl, 3,3′,4,4′-tetrachlorobiphe...

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Veröffentlicht in:	Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Comparative pharmacology and toxicology, 1998-11, Vol.121 (1), p.405-412
Hauptverfasser:	Gorman, Nadia, Walton, Heidi S., Sinclair, Jacqueline F., Sinclair, Peter R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alligator Anas Animals Catalysis Chick Cross Reactions CYP1A Cytochrome P-450 Enzyme System - immunology Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Duck Freshwater Microsomes, Liver - drug effects Microsomes, Liver - enzymology Oxidation-Reduction Polychlorinated Biphenyls - pharmacology Scup Species Specificity Uroporphyrin Uroporphyrinogen Uroporphyrinogens - metabolism Vertebrates
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