Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder
Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. 1 An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme. 2,3 A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder s...
Gespeichert in:
| Veröffentlicht in: | Molecular psychiatry 1998-07, Vol.3 (4), p.342-345 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 345 |
|---|---|
| container_issue | 4 |
| container_start_page | 342 |
| container_title | Molecular psychiatry |
| container_volume | 3 |
| creator | Kirov, G Murphy, K C Arranz, M J Jones, I McCandles, F Kunugi, H Murray, R M McGuffin, P Collier, D A Owen, M J Craddock, N |
| description | Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines.
1
An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme.
2,3
A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder suggested that the Met (low activity) COMT allele might be associated with rapid-cycling in this population.
4
We therefore tested the hypothesis that the Met allele might be associated with rapid cycling bipolar disorder in the wider population. We studied a sample of British Caucasian DSM-IV bipolar patients, of whom 55 met criteria for rapid cycling at some time during the illness and 110 met stringent criteria for a definite non-rapid cycling course. The COMT genotype was determined using a PCR assay. The low activity allele was more frequent in the group of rapid cyclers: 0.55
vs
0.42 (one-tailed χ
2
= 5.12, d.f. = 1,
P
= 0.012), and bearers of low activity alleles showed a dose-dependent increased risk of lifetime occurrence of rapid cycling: χ
2
test of linear association = 4.84, d.f. = 1,
P
= 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder. |
| doi_str_mv | 10.1038/sj.mp.4000385 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17208237</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17208237</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-a8e6f55c4b8f5ed8f4de8e67ecb5ac27322b2ce218b5659d0cc650fa746f3baa3</originalsourceid><addsrcrecordid>eNptkM2LFDEQxYMo67p69CgEFG89ptOpTs9RlvUDBvai55BOV2YypDttqsdl_nuzTOOCeKqP9-NV8Rh7W4tNLZruEx0347xRQpQBnrHrWum2AtDd89I3sK1U3amX7BXRUYhHEa7Y1VYLqZW6ZvtdeuDWLeF3WM7cxogRefLc2QXdIcXqvhpxOZzjku1EHrMl5HuckFui5ELBBv4QlgPPdg4Dd2cXw7TnfZhTtJkPgVIeML9mL7yNhG_WesN-frn7cfut2t1__X77eVc5BWqpbIetB3Cq7zzg0Hk1YFlpdD1YJ3UjZS8dyrrroYXtIJxrQXirVeub3trmhn28-M45_TohLWYM5DBGO2E6kam1FJ1sdAHf_wMe0ylP5TcjWwUapAAoVHWhXE5EGb2ZcxhtPptamMf4DR3NOJs1_sK_W11P_YjDX3rNu-gfVt2Ss9GXUF2gJ9OuARB1wTYXjIoy7TE_Pff_u38Azhue8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645752055</pqid></control><display><type>article</type><title>Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kirov, G ; Murphy, K C ; Arranz, M J ; Jones, I ; McCandles, F ; Kunugi, H ; Murray, R M ; McGuffin, P ; Collier, D A ; Owen, M J ; Craddock, N</creator><creatorcontrib>Kirov, G ; Murphy, K C ; Arranz, M J ; Jones, I ; McCandles, F ; Kunugi, H ; Murray, R M ; McGuffin, P ; Collier, D A ; Owen, M J ; Craddock, N</creatorcontrib><description>Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines.
1
An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme.
2,3
A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder suggested that the Met (low activity) COMT allele might be associated with rapid-cycling in this population.
4
We therefore tested the hypothesis that the Met allele might be associated with rapid cycling bipolar disorder in the wider population. We studied a sample of British Caucasian DSM-IV bipolar patients, of whom 55 met criteria for rapid cycling at some time during the illness and 110 met stringent criteria for a definite non-rapid cycling course. The COMT genotype was determined using a PCR assay. The low activity allele was more frequent in the group of rapid cyclers: 0.55
vs
0.42 (one-tailed χ
2
= 5.12, d.f. = 1,
P
= 0.012), and bearers of low activity alleles showed a dose-dependent increased risk of lifetime occurrence of rapid cycling: χ
2
test of linear association = 4.84, d.f. = 1,
P
= 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4000385</identifier><identifier>PMID: 9702744</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Amino Acid Substitution ; Amino acids ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Bipolar disorder ; Bipolar Disorder - enzymology ; Bipolar Disorder - epidemiology ; Bipolar Disorder - genetics ; Bipolar Disorder - psychology ; Bipolar disorders ; Catechol ; Catechol O-methyltransferase ; Catechol O-Methyltransferase - genetics ; Catecholamines ; Female ; Gene polymorphism ; Humans ; Hypotheses ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Methionine ; Methyltransferase ; Middle Aged ; Mood disorders ; Neurosciences ; original-research-article ; Pharmacotherapy ; Point Mutation ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Population genetics ; Population studies ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Assessment ; United Kingdom ; Whites</subject><ispartof>Molecular psychiatry, 1998-07, Vol.3 (4), p.342-345</ispartof><rights>Macmillan Publishers Limited 1998</rights><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a8e6f55c4b8f5ed8f4de8e67ecb5ac27322b2ce218b5659d0cc650fa746f3baa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4000385$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4000385$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1835501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9702744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirov, G</creatorcontrib><creatorcontrib>Murphy, K C</creatorcontrib><creatorcontrib>Arranz, M J</creatorcontrib><creatorcontrib>Jones, I</creatorcontrib><creatorcontrib>McCandles, F</creatorcontrib><creatorcontrib>Kunugi, H</creatorcontrib><creatorcontrib>Murray, R M</creatorcontrib><creatorcontrib>McGuffin, P</creatorcontrib><creatorcontrib>Collier, D A</creatorcontrib><creatorcontrib>Owen, M J</creatorcontrib><creatorcontrib>Craddock, N</creatorcontrib><title>Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines.
1
An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme.
2,3
A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder suggested that the Met (low activity) COMT allele might be associated with rapid-cycling in this population.
4
We therefore tested the hypothesis that the Met allele might be associated with rapid cycling bipolar disorder in the wider population. We studied a sample of British Caucasian DSM-IV bipolar patients, of whom 55 met criteria for rapid cycling at some time during the illness and 110 met stringent criteria for a definite non-rapid cycling course. The COMT genotype was determined using a PCR assay. The low activity allele was more frequent in the group of rapid cyclers: 0.55
vs
0.42 (one-tailed χ
2
= 5.12, d.f. = 1,
P
= 0.012), and bearers of low activity alleles showed a dose-dependent increased risk of lifetime occurrence of rapid cycling: χ
2
test of linear association = 4.84, d.f. = 1,
P
= 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Amino Acid Substitution</subject><subject>Amino acids</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - enzymology</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar disorders</subject><subject>Catechol</subject><subject>Catechol O-methyltransferase</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Catecholamines</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methionine</subject><subject>Methyltransferase</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neurosciences</subject><subject>original-research-article</subject><subject>Pharmacotherapy</subject><subject>Point Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Population studies</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Assessment</subject><subject>United Kingdom</subject><subject>Whites</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM2LFDEQxYMo67p69CgEFG89ptOpTs9RlvUDBvai55BOV2YypDttqsdl_nuzTOOCeKqP9-NV8Rh7W4tNLZruEx0347xRQpQBnrHrWum2AtDd89I3sK1U3amX7BXRUYhHEa7Y1VYLqZW6ZvtdeuDWLeF3WM7cxogRefLc2QXdIcXqvhpxOZzjku1EHrMl5HuckFui5ELBBv4QlgPPdg4Dd2cXw7TnfZhTtJkPgVIeML9mL7yNhG_WesN-frn7cfut2t1__X77eVc5BWqpbIetB3Cq7zzg0Hk1YFlpdD1YJ3UjZS8dyrrroYXtIJxrQXirVeub3trmhn28-M45_TohLWYM5DBGO2E6kam1FJ1sdAHf_wMe0ylP5TcjWwUapAAoVHWhXE5EGb2ZcxhtPptamMf4DR3NOJs1_sK_W11P_YjDX3rNu-gfVt2Ss9GXUF2gJ9OuARB1wTYXjIoy7TE_Pff_u38Azhue8g</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Kirov, G</creator><creator>Murphy, K C</creator><creator>Arranz, M J</creator><creator>Jones, I</creator><creator>McCandles, F</creator><creator>Kunugi, H</creator><creator>Murray, R M</creator><creator>McGuffin, P</creator><creator>Collier, D A</creator><creator>Owen, M J</creator><creator>Craddock, N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope></search><sort><creationdate>19980701</creationdate><title>Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder</title><author>Kirov, G ; Murphy, K C ; Arranz, M J ; Jones, I ; McCandles, F ; Kunugi, H ; Murray, R M ; McGuffin, P ; Collier, D A ; Owen, M J ; Craddock, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-a8e6f55c4b8f5ed8f4de8e67ecb5ac27322b2ce218b5659d0cc650fa746f3baa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Amino Acid Substitution</topic><topic>Amino acids</topic><topic>Behavioral Sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - enzymology</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar disorders</topic><topic>Catechol</topic><topic>Catechol O-methyltransferase</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Catecholamines</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methionine</topic><topic>Methyltransferase</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neurosciences</topic><topic>original-research-article</topic><topic>Pharmacotherapy</topic><topic>Point Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Population studies</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Assessment</topic><topic>United Kingdom</topic><topic>Whites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirov, G</creatorcontrib><creatorcontrib>Murphy, K C</creatorcontrib><creatorcontrib>Arranz, M J</creatorcontrib><creatorcontrib>Jones, I</creatorcontrib><creatorcontrib>McCandles, F</creatorcontrib><creatorcontrib>Kunugi, H</creatorcontrib><creatorcontrib>Murray, R M</creatorcontrib><creatorcontrib>McGuffin, P</creatorcontrib><creatorcontrib>Collier, D A</creatorcontrib><creatorcontrib>Owen, M J</creatorcontrib><creatorcontrib>Craddock, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirov, G</au><au>Murphy, K C</au><au>Arranz, M J</au><au>Jones, I</au><au>McCandles, F</au><au>Kunugi, H</au><au>Murray, R M</au><au>McGuffin, P</au><au>Collier, D A</au><au>Owen, M J</au><au>Craddock, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>3</volume><issue>4</issue><spage>342</spage><epage>345</epage><pages>342-345</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines.
1
An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme.
2,3
A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder suggested that the Met (low activity) COMT allele might be associated with rapid-cycling in this population.
4
We therefore tested the hypothesis that the Met allele might be associated with rapid cycling bipolar disorder in the wider population. We studied a sample of British Caucasian DSM-IV bipolar patients, of whom 55 met criteria for rapid cycling at some time during the illness and 110 met stringent criteria for a definite non-rapid cycling course. The COMT genotype was determined using a PCR assay. The low activity allele was more frequent in the group of rapid cyclers: 0.55
vs
0.42 (one-tailed χ
2
= 5.12, d.f. = 1,
P
= 0.012), and bearers of low activity alleles showed a dose-dependent increased risk of lifetime occurrence of rapid cycling: χ
2
test of linear association = 4.84, d.f. = 1,
P
= 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>9702744</pmid><doi>10.1038/sj.mp.4000385</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 1998-07, Vol.3 (4), p.342-345 |
| issn | 1359-4184 1476-5578 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17208237 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult and adolescent clinical studies Alleles Amino Acid Substitution Amino acids Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - enzymology Bipolar Disorder - epidemiology Bipolar Disorder - genetics Bipolar Disorder - psychology Bipolar disorders Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - genetics Catecholamines Female Gene polymorphism Humans Hypotheses Male Medical sciences Medicine Medicine & Public Health Methionine Methyltransferase Middle Aged Mood disorders Neurosciences original-research-article Pharmacotherapy Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Population genetics Population studies Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Assessment United Kingdom Whites |
| title | Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A48%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20activity%20allele%20of%20catechol-O-methyltransferase%20gene%20associated%20with%20rapid%20cycling%20bipolar%20disorder&rft.jtitle=Molecular%20psychiatry&rft.au=Kirov,%20G&rft.date=1998-07-01&rft.volume=3&rft.issue=4&rft.spage=342&rft.epage=345&rft.pages=342-345&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/sj.mp.4000385&rft_dat=%3Cproquest_cross%3E17208237%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2645752055&rft_id=info:pmid/9702744&rfr_iscdi=true |