Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

Hypoxia‐inducible factor 1 α (HIF1α) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen. Transfection analysis using fusion genes of GAL4DBD with various fragments of the two factors delineated two transcription activation domains wh...

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Veröffentlicht in:	The EMBO journal 1999-04, Vol.18 (7), p.1905-1914
Hauptverfasser:	Ema, Masatsugu, Hirota, Kiichi, Mimura, Junsei, Abe, Hisaku, Yodoi, Junji, Sogawa, Kazuhiro, Poellinger, Lorenz, Fujii-Kuriyama, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	oxygen sensing protein stabilization redox regulation sulfhydryl modification thioredoxin
Online-Zugang:	Volltext
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