The Ets Transcription Factor ERM Is Th1-Specific and Induced by IL-12 Through a Stat4-Dependent Pathway

Interleukin 12 (IL-12)-induced T helper 1 (Th1) development requires Stat4 activation. However, antigen-activated Th1 cells can produce interferon γ (IFN-γ) independently of IL-12 and Stat4 activation. Thus, in differentiated Th1 cells, factors regulated by IL-12 and Stat4 may be involved in IFN-γ p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-03, Vol.96 (7), p.3888-3893
Hauptverfasser:	Ouyang, Wenjun, Jacobson, Nils G., Bhattacharya, Deepta, Gorham, James D., Fenoglio, Domenic, Sha, William C., Murphy, Theresa L., Murphy, Kenneth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cells Cloning, Molecular Complementary DNA Cytokines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genes Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-12 - pharmacology Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Knockout Mice, Transgenic Ova Proteins Recombinant Proteins - metabolism RNA Signal Transduction - immunology Spleen - immunology Splenocytes STAT1 Transcription Factor STAT4 Transcription Factor T cell antigen receptors T lymphocytes Th1 Cells - immunology Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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