Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems

The aim of this work was to study the mechanism of cross-modulation between cannabinoid and opioid systems for analgesia during acute and chronic exposure. Acute coadministration of ineffectual subanalgesic doses of the synthetic cannabinoid CP-55,940 (0.2 mg/kg i.p.) and morphine (2.5 mg/kg i.p.) r...

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Veröffentlicht in:	Psychopharmacologia 2005-11, Vol.182 (4), p.527-536
Hauptverfasser:	VIGANO, Daniela, RUBINO, Tiziana, VACCANI, Angelo, BIANCHESSI, Silvia, MARMORATO, Patrick, CASTIGLIONI, Chiara, PAROLARO, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Behavior, Animal - drug effects Biological and medical sciences Brain - anatomy & histology Brain - drug effects Brain Chemistry - drug effects Cannabinoids - pharmacology Cyclic AMP - metabolism Cyclohexanols - pharmacokinetics Cyclohexanols - pharmacology Dose-Response Relationship, Drug Drug addictions Drug Administration Schedule Drug Interactions Enkephalin, Ala-MePhe-Gly- - pharmacokinetics Enkephalin, Ala-MePhe-Gly- - pharmacology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Male Medical sciences Narcotics - pharmacology Pain Measurement - drug effects Radioligand Assay - methods Rats Rats, Sprague-Dawley Receptors, Cannabinoid - physiology Receptors, Opioid - physiology Sulfur Isotopes - pharmacokinetics Toxicology Tritium - pharmacokinetics
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