HORSE SPECIES SYMPOSIUM: Glucocorticoid programming of hypothalamic-pituitary-adrenal axis and metabolic function: Animal studies from mouse to horse
Adrenal glucocorticoids, such as cortisol, are essential for normal fetal development and for maintaining homeostasis in adults. Developmental studies in humans and other animals have shown that exposure to excess glucocorticoids during critical windows of perinatal development can program permanent...
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| Veröffentlicht in: | Journal of animal science 2015-07, Vol.93 (7), p.3245-3260 |
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| container_title | Journal of animal science |
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| creator | Jellyman, J K Valenzuela, O A Fowden, A L |
| description | Adrenal glucocorticoids, such as cortisol, are essential for normal fetal development and for maintaining homeostasis in adults. Developmental studies in humans and other animals have shown that exposure to excess glucocorticoids during critical windows of perinatal development can program permanent changes in hypothalamic-pituitary-adrenal (HPA) axis function and metabolic function, with adverse implications for the long-term health of the exposed offspring. The current review compares the programming of postnatal HPA axis function and glucose homeostasis among different species overexposed perinatally to glucocorticoids, with emphasis on the horse. The potential role of epigenetic modification of genes involved in the regulation of HPA axis and metabolic function at cellular and molecular levels is also discussed. |
| doi_str_mv | 10.2527/jas.2014-8612 |
| format | Article |
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The potential role of epigenetic modification of genes involved in the regulation of HPA axis and metabolic function at cellular and molecular levels is also discussed.</description><subject>Animals</subject><subject>Female</subject><subject>Glucocorticoids - metabolism</subject><subject>Glucose - metabolism</subject><subject>Horses - physiology</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Pregnancy</subject><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAYRS0kxHtkRR5ZAn7FjdlQVUolUCtCB6bqs-NSozgOtiPRH8L_JRIw3eXo6p6L0CUlN6xkk9sPSDeMUFFUkrIDdEJLVhacSn6MTlP6IISyUpVH6JhJwZVS_AR9Py5f6hmuV7PpYlbj-u15tawX6-c7PG8HE0yI2ZngGtzH8B7Be9e947DFu30f8g5a8M4UvcuDyxD3BTTRdtBi-HIJQ9dgbzPo0DqDt0NnsgvdHb7vnB-ZlIfG2YS3MXjsw5AszgHvQkz2HB1uoU324i_P0Pph9jp9LJ6W88X0_qnoWUVzwRSISpFGEFUBFxWhsiy14RNLGg6SSCoEUAmWN0xyqVklLSuN0kZrzYXmZ-j6t3e0-xxsyhvvkrFtC50dB23ohBExPkvViF79oYP2ttn0cZSI-83_lfwHV7h00Q</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Jellyman, J K</creator><creator>Valenzuela, O A</creator><creator>Fowden, A L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201507</creationdate><title>HORSE SPECIES SYMPOSIUM: Glucocorticoid programming of hypothalamic-pituitary-adrenal axis and metabolic function: Animal studies from mouse to horse</title><author>Jellyman, J K ; Valenzuela, O A ; Fowden, A L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p281t-29a4890d4098a34801655bc37e0d3a606144a16ae3d2636b286e25c9bcbbb34b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Female</topic><topic>Glucocorticoids - metabolism</topic><topic>Glucose - metabolism</topic><topic>Horses - physiology</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jellyman, J K</creatorcontrib><creatorcontrib>Valenzuela, O A</creatorcontrib><creatorcontrib>Fowden, A L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jellyman, J K</au><au>Valenzuela, O A</au><au>Fowden, A L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HORSE SPECIES SYMPOSIUM: Glucocorticoid programming of hypothalamic-pituitary-adrenal axis and metabolic function: Animal studies from mouse to horse</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>2015-07</date><risdate>2015</risdate><volume>93</volume><issue>7</issue><spage>3245</spage><epage>3260</epage><pages>3245-3260</pages><eissn>1525-3163</eissn><abstract>Adrenal glucocorticoids, such as cortisol, are essential for normal fetal development and for maintaining homeostasis in adults. 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| fulltext | fulltext |
| identifier | EISSN: 1525-3163 |
| ispartof | Journal of animal science, 2015-07, Vol.93 (7), p.3245-3260 |
| issn | 1525-3163 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1720452719 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Animals Female Glucocorticoids - metabolism Glucose - metabolism Horses - physiology Hydrocortisone - metabolism Hypothalamo-Hypophyseal System - physiology Pituitary-Adrenal System - physiology Pregnancy |
| title | HORSE SPECIES SYMPOSIUM: Glucocorticoid programming of hypothalamic-pituitary-adrenal axis and metabolic function: Animal studies from mouse to horse |
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