Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas

Context: The somatic landscape of pituitary adenomas is largely unknown. Identification of somatic alterations aims at better understanding of tumor pathology. Objective: The objective of the study was a genome-wide characterization of somatic single-nucleotide variants, structural variants, and cop...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2015-10, Vol.100 (10), p.3918-3927
Hauptverfasser:	Välimäki, Niko, Demir, Hande, Pitkänen, Esa, Kaasinen, Eevi, Karppinen, Atte, Kivipelto, Leena, Schalin-Jäntti, Camilla, Aaltonen, Lauri A, Karhu, Auli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adolescent Adult Aged Chromogranins Female Genome, Human Growth Hormone-Secreting Pituitary Adenoma - genetics Growth Hormone-Secreting Pituitary Adenoma - pathology GTP-Binding Protein alpha Subunits, Gs - genetics Humans Male Middle Aged Mutation Polymorphism, Single Nucleotide Sequence Analysis, DNA Young Adult
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