Highly Sensitive and Selective Sensor Chips with Graphene-Oxide Linking Layer

The development of sensing interfaces can significantly improve the performance of biological sensors. Graphene oxide provides a remarkable immobilization platform for surface plasmon resonance (SPR) biosensors due to its excellent optical and biochemical properties. Here, we describe a novel sensor...

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Veröffentlicht in:ACS applied materials & interfaces 2015-10, Vol.7 (39), p.21727-21734
Hauptverfasser: Stebunov, Yury V, Aftenieva, Olga A, Arsenin, Aleksey V, Volkov, Valentyn S
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container_issue 39
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container_title ACS applied materials & interfaces
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creator Stebunov, Yury V
Aftenieva, Olga A
Arsenin, Aleksey V
Volkov, Valentyn S
description The development of sensing interfaces can significantly improve the performance of biological sensors. Graphene oxide provides a remarkable immobilization platform for surface plasmon resonance (SPR) biosensors due to its excellent optical and biochemical properties. Here, we describe a novel sensor chip for SPR biosensors based on graphene-oxide linking layers. The biosensing assay model was based on a graphene oxide film containing streptavidin. The proposed sensor chip has three times higher sensitivity than the carboxymethylated dextran surface of a commercial sensor chip. Moreover, the demonstrated sensor chips are bioselective with more than 25 times reduced binding for nonspecific interaction and can be used multiple times. We consider the results presented here of importance for any future applications of highly sensitive SPR biosensing.
doi_str_mv 10.1021/acsami.5b04427
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subjects Adsorption
Equipment Design
Graphite - chemistry
Oxides - chemistry
Sensitivity and Specificity
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
title Highly Sensitive and Selective Sensor Chips with Graphene-Oxide Linking Layer
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