The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR

The identification of MUC1 tumor-associated Tn antigen (αGalpNAc1-O-Ser/Thr) has boosted the development of anticancer vaccines. Combining microarrays and saturation transfer difference NMR, we have characterized the fine-epitope mapping of a MUC1 chemical library (naked and Tn-glycosylated) toward...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-10, Vol.137 (39), p.12438-12441
Hauptverfasser:	Coelho, Helena, Matsushita, Takahiko, Artigas, Gerard, Hinou, Hiroshi, Cañada, F. Javier, Lo-Man, Richard, Leclerc, Claude, Cabrita, Eurico J, Jiménez-Barbero, Jesús, Nishimura, Shin-Ichiro, Garcia-Martín, Fayna, Marcelo, Filipa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Cancer Vaccines Epitope Mapping Epitopes - immunology Humans Magnetic Resonance Spectroscopy Protein Array Analysis
Online-Zugang:	Volltext
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