A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

Smad proteins are essential components of the signalling cascade initiated by members of the Transforming Growth Factor-beta family. TGFbeta binding to heteromeric complexes of transmembrane Ser/Thr kinases induces Smad2 and Smad3 phosphorylation on their C terminus residues. This phosphorylation le...

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Veröffentlicht in:	Oncogene 1999-02, Vol.18 (8), p.1643-1648
Hauptverfasser:	DENNLER, S, HUET, S, GAUTHIER, J.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Amino Acid Sequence Biological and medical sciences Biological Transport Biopolymers C-Terminus Cell Nucleus - metabolism Cell physiology DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Sequence Data Multigene Family Nucleotide sequence Oligomerization Phosphorylation Plasminogen Activator Inhibitor 1 - genetics Promoter Regions, Genetic Protein Processing, Post-Translational Recombinant Fusion Proteins - biosynthesis Regulatory Sequences, Nucleic Acid Responses to growth factors, tumor promotors, other factors Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Smad protein Smad2 Protein Smad3 Protein Smad4 protein Structure-Activity Relationship Trans-Activators - chemistry Trans-Activators - genetics Transforming Growth Factor beta - physiology Transforming growth factor-b
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