Identification of a 57-kilodalton selenoprotein in human thyrocytes as thioredoxin reductase and evidence that its expression is regulated through the calcium-phosphoinositol signaling pathway

Human thyrocytes incubated with the phorbol ester, phorbol 12-myristate 13-acetate (PMA; 10(-5)-10(-8) mol/L) and the calcium ionophore A23187 (10(-5)-10(-8) mol/L) showed a marked increase in the expression of a 57-kDa selenoprotein identified as thioredoxin reductase (TR). After the addition of A2...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1998-06, Vol.83 (6), p.2052-2058
Hauptverfasser:	HOWIE, A. F, ARTHUR, J. R, NICOL, F, WALKER, S. W, BEECH, S. G, BECKETT, G. J
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Biological and medical sciences Calcimycin - pharmacology Calcium - metabolism Cells, Cultured Fundamental and applied biological sciences. Psychology Hormones. Regulation Humans Ionophores - pharmacology Kinetics Phosphatidylinositols - metabolism Signal Transduction Tetradecanoylphorbol Acetate - pharmacology Thioredoxin-Disulfide Reductase - analysis Thioredoxin-Disulfide Reductase - metabolism Thyroid Gland - enzymology Thyroid. Parathyroid. Ultimobranchial body Thyrotropin - pharmacology Vertebrates: endocrinology
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