Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK
While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May...
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| Veröffentlicht in: | Acta dermato-venereologica 2015-09, Vol.95 (7), p.830-834 |
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| creator | Wallingford, Sarah C Russell, Sheila A Vail, Andy Proby, Charlotte M Lear, John T Green, Adèle C |
| description | While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals in Manchester, UK, counting AKs and recording field change presence by body site and SCCs arising during the study period. Of the participants 130 (29%) had AKs at examination. In 60 (13%) RTR patients with AKs but no field change, 4 (7%) developed SCCs, compared with 15 (21%) of the 70 (15%) with AKs and field change. SCCs developed directly within field change areas in 11/15 (73%) RTRs. This study confirms that RTRs with widespread confluent actinic skin damage are at very high risk of SCC and should be monitored closely. |
| doi_str_mv | 10.2340/00015555-2098 |
| format | Article |
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This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals in Manchester, UK, counting AKs and recording field change presence by body site and SCCs arising during the study period. Of the participants 130 (29%) had AKs at examination. In 60 (13%) RTR patients with AKs but no field change, 4 (7%) developed SCCs, compared with 15 (21%) of the 70 (15%) with AKs and field change. SCCs developed directly within field change areas in 11/15 (73%) RTRs. 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This study confirms that RTRs with widespread confluent actinic skin damage are at very high risk of SCC and should be monitored closely.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Keratosis, Actinic - epidemiology</subject><subject>Keratosis, Actinic - pathology</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Time Factors</subject><subject>Transplant Recipients</subject><subject>Young Adult</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQtBCIlsKRK_KRQwN2EjvxsUK8RBEXeo62jk0NiZPajhA_wHfjqC172ceMZncHoUtKbtIsJ7eEEMpiJCkR5RGaUs5orFlxjKYjlozgBJ15_xnblNHyFE1SVpR57KbodyGDsUbiL-UgdF75OYb9SBvV1FhuwH4oDLbG4H0nDQTTWY-_Tdhgvx2g7QaPpWoaLMFJY7sWsLHYKQsNDg6s7xuwIQ6k6Y2ywY_wK1i5UT4oN8erl3N0oqHx6mKfZ2j1cP9-95Qs3x6f7xbLRGZZGhKdA7D41Bp4XeRZQYuS1FxQnXPJNS-VIKrUWmRapLJWOl_rugAAyoVmuSDZDF3vdHvXbYe4vmqNH28Hq-IbFS2oEAVjhEdqsqNK13nvlK56Z1pwPxUl1Wh9dbC-Gq2P_Ku99LBuVf3PPnid_QFMzoBa</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Wallingford, Sarah C</creator><creator>Russell, Sheila A</creator><creator>Vail, Andy</creator><creator>Proby, Charlotte M</creator><creator>Lear, John T</creator><creator>Green, Adèle C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK</title><author>Wallingford, Sarah C ; Russell, Sheila A ; Vail, Andy ; Proby, Charlotte M ; Lear, John T ; Green, Adèle C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-f4aa5001ba6d74371780d691f46c6f68e90e8ff93f92cdef4bfd7aaa169f54903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Keratosis, Actinic - epidemiology</topic><topic>Keratosis, Actinic - pathology</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Time Factors</topic><topic>Transplant Recipients</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallingford, Sarah C</creatorcontrib><creatorcontrib>Russell, Sheila A</creatorcontrib><creatorcontrib>Vail, Andy</creatorcontrib><creatorcontrib>Proby, Charlotte M</creatorcontrib><creatorcontrib>Lear, John T</creatorcontrib><creatorcontrib>Green, Adèle C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallingford, Sarah C</au><au>Russell, Sheila A</au><au>Vail, Andy</au><au>Proby, Charlotte M</au><au>Lear, John T</au><au>Green, Adèle C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>95</volume><issue>7</issue><spage>830</spage><epage>834</epage><pages>830-834</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><abstract>While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals in Manchester, UK, counting AKs and recording field change presence by body site and SCCs arising during the study period. Of the participants 130 (29%) had AKs at examination. In 60 (13%) RTR patients with AKs but no field change, 4 (7%) developed SCCs, compared with 15 (21%) of the 70 (15%) with AKs and field change. SCCs developed directly within field change areas in 11/15 (73%) RTRs. This study confirms that RTRs with widespread confluent actinic skin damage are at very high risk of SCC and should be monitored closely.</abstract><cop>Sweden</cop><pmid>25784002</pmid><doi>10.2340/00015555-2098</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology England - epidemiology Female Humans Keratosis, Actinic - epidemiology Keratosis, Actinic - pathology Kidney Transplantation - adverse effects Male Middle Aged Prevalence Risk Assessment Risk Factors Severity of Illness Index Skin - pathology Skin Neoplasms - epidemiology Skin Neoplasms - pathology Time Factors Transplant Recipients Young Adult |
| title | Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK |
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