Diarrheagenicity evaluation of attenuated Vibrio cholerae O1 and O139 strains in the human intestine ex vivo

The recent spread of El Tor cholera in Latin America highlights the need for a safe and economical vaccine. The main approach for developing live recombinant vaccines has been to disarm known pathogenic strains of cholera toxin leaving intact antigens involved in protection. These recombinant vaccin...

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Veröffentlicht in:	Vaccine 1999-02, Vol.17 (7), p.949-956
Hauptverfasser:	Burgos, J.M, Perez, J.L, Garcia, L, Gonzalez, G.S, Benitez, J.A, Galindo, F, Silberstein, C, Ibarra, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholera Vaccines - toxicity Diarrhea - immunology Diarrhea - metabolism Diarrhea - microbiology Disease Models, Animal Human intestine Humans Ileum - immunology Ileum - metabolism Ileum - microbiology In Vitro Techniques Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Lethal Dose 50 Mice Rabbits Short circuit current Vaccine development Vaccines, Attenuated - toxicity Vibrio cholerae Vibrio cholerae - immunology Vibrio cholerae - pathogenicity Water permeability
Online-Zugang:	Volltext
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