Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity
Agmatine treatment is known to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove to be neuroprotective in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mode...
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| Veröffentlicht in: | Neurochemical research 2005-06, Vol.30 (6-7), p.713-719 |
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| creator | Gilad, Gad M Gilad, Varda H Finberg, John P M Rabey, Jose M |
| description | Agmatine treatment is known to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove to be neuroprotective in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. Concomitant daily treatment (intraperitoneal injections) with agmatine (100 mg/kg for 5 days) and MPTP (40 mg/kg for 2 days) exacerbated MPTP-related toxicity as evidenced by a larger reduction in dopamine uptake into striatal synaptosomes (42.4% as compared to 58.3% of control, respectively). In contrast, agmatine treatment commencing after MPTP, produced partial protection (31%) against MPTP dopaminergic toxicity. The findings implicate agmatine in mechanisms regulating MPTP neurotoxicity, but underscore the characteristic neuroprotective efficacy of agmatine when applied after the insult. |
| doi_str_mv | 10.1007/s11064-005-6865-9 |
| format | Article |
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Agmatine - pharmacology Animals Corpus Striatum - drug effects Corpus Striatum - enzymology Corpus Striatum - metabolism Corpus Striatum - pathology Dopamine - metabolism Male Mice Mice, Inbred C57BL Monoamine Oxidase - metabolism Neuroprotective Agents - pharmacology Nitric Oxide Synthase - metabolism Parkinson Disease - etiology Receptors, N-Methyl-D-Aspartate - metabolism |
| title | Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity |
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