Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury

Lamiophlomis rotata (Benth.) Kudo (L. rotata) is a medical plant that has been traditionally used for centuries for the treatment of pain, such as bone and muscle pain, joint pain and dysmenorrhea. Although iridoid glycosides of L. rotata (IGLR) are the major active components of it according to rep...

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Veröffentlicht in:	Journal of ethnopharmacology 2015-09, Vol.173, p.204-211
Hauptverfasser:	Zheng, Yanan, Yin, Xuefei, Huo, Fuquan, Xiong, Hui, Mei, Zhinan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analgesics - therapeutic use Animals Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - genetics Cyclic GMP-Dependent Protein Kinases - metabolism Cytokines - metabolism Iridoid glycosides Iridoid Glycosides - pharmacology Iridoid Glycosides - therapeutic use Lamiaceae Lamiophlomis rotate (Benth.) Kudo Male Motor Activity - drug effects Neuralgia - drug therapy Neuralgia - metabolism Neuropathic pain Nitric Oxide - metabolism Nitric Oxide Synthase Type II - genetics NMDAR/PKC NO/cGMP/PKG Peripheral Nerve Injuries - drug therapy Peripheral Nerve Injuries - metabolism Protein Kinase C - metabolism Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - metabolism Rotarod Performance Test Spared nerve injury Spinal Cord - drug effects Spinal Cord - metabolism
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