Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclide therapy

Abstract Introduction Sigma receptors are overexpressed in a variety of human tumors, making them potential targets for radionuclide receptor therapy. We have previously synthesized and evaluated131 I-labeled (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[131 I] p IV], which has a high affinit...

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