Sequential changes in anti-GAL-1 staining of the rat organ of Corti following amikacin exposure
Hair cell loss and a non-functional epithelial reorganization appeared in the organ of Corti after acoustic or toxic damage. Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial c...
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| Veröffentlicht in: | Brain research 1999-03, Vol.822 (1), p.43-51 |
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| creator | Bartolomé, M.Visitación Vago, Philippe Gil-Loyzaga, Pablo Humbert, Gullienne Joubert-Caron, Raymonde Pujol, Rémy Lenoir, Marc |
| description | Hair cell loss and a non-functional epithelial reorganization appeared in the organ of Corti after acoustic or toxic damage. Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial cells. The phenotype of these atypical cells has been now investigated by using the galectine 1 (GAL-1) antibody. In the normal organ of Corti, this antibody recognizes all the epithelial cells except the sensory hair cells and their supporting cells. At PD 21, transient atypical cells were not stained by GAL-1 antibody, suggesting that they were originated from hair cells or their supporting cells. Later, the organ of Corti was substituted by an epithelial scare, GAL-1 stained. This study also emphasizes the particular resistance of the cochlear apex to degeneration after antibiotic intoxication. |
| doi_str_mv | 10.1016/S0006-8993(99)01070-7 |
| format | Article |
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Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial cells. The phenotype of these atypical cells has been now investigated by using the galectine 1 (GAL-1) antibody. In the normal organ of Corti, this antibody recognizes all the epithelial cells except the sensory hair cells and their supporting cells. At PD 21, transient atypical cells were not stained by GAL-1 antibody, suggesting that they were originated from hair cells or their supporting cells. Later, the organ of Corti was substituted by an epithelial scare, GAL-1 stained. This study also emphasizes the particular resistance of the cochlear apex to degeneration after antibiotic intoxication.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)01070-7</identifier><identifier>PMID: 10082882</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amikacin - pharmacology ; Animals ; Anti-Bacterial Agents - pharmacology ; Antibodies, Monoclonal ; Biological and medical sciences ; Cochlea ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Epithelial Cells - chemistry ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Fundamental and applied biological sciences. Psychology ; Galectins ; Hemagglutinins - analysis ; Hemagglutinins - immunology ; Hemagglutinins - metabolism ; Lectin ; Lectins ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Organ of Corti - cytology ; Organ of Corti - drug effects ; Organ of Corti - ultrastructure ; Ototoxicity ; Paraffin Embedding ; Rat ; Rats ; Rats, Wistar ; Transdifferentiation ; Vertebrates: nervous system and sense organs ; β-galactoside</subject><ispartof>Brain research, 1999-03, Vol.822 (1), p.43-51</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6860add93e39e2e9a42859b696e640db1c211ef3e1cf1946d11d9bfe85a35a8a3</citedby><cites>FETCH-LOGICAL-c421t-6860add93e39e2e9a42859b696e640db1c211ef3e1cf1946d11d9bfe85a35a8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(99)01070-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1729038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10082882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bartolomé, M.Visitación</creatorcontrib><creatorcontrib>Vago, Philippe</creatorcontrib><creatorcontrib>Gil-Loyzaga, Pablo</creatorcontrib><creatorcontrib>Humbert, Gullienne</creatorcontrib><creatorcontrib>Joubert-Caron, Raymonde</creatorcontrib><creatorcontrib>Pujol, Rémy</creatorcontrib><creatorcontrib>Lenoir, Marc</creatorcontrib><title>Sequential changes in anti-GAL-1 staining of the rat organ of Corti following amikacin exposure</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Hair cell loss and a non-functional epithelial reorganization appeared in the organ of Corti after acoustic or toxic damage. Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial cells. The phenotype of these atypical cells has been now investigated by using the galectine 1 (GAL-1) antibody. In the normal organ of Corti, this antibody recognizes all the epithelial cells except the sensory hair cells and their supporting cells. At PD 21, transient atypical cells were not stained by GAL-1 antibody, suggesting that they were originated from hair cells or their supporting cells. Later, the organ of Corti was substituted by an epithelial scare, GAL-1 stained. This study also emphasizes the particular resistance of the cochlear apex to degeneration after antibiotic intoxication.</description><subject>Amikacin - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cochlea</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Epithelial Cells - chemistry</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galectins</subject><subject>Hemagglutinins - analysis</subject><subject>Hemagglutinins - immunology</subject><subject>Hemagglutinins - metabolism</subject><subject>Lectin</subject><subject>Lectins</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Organ of Corti - cytology</subject><subject>Organ of Corti - drug effects</subject><subject>Organ of Corti - ultrastructure</subject><subject>Ototoxicity</subject><subject>Paraffin Embedding</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Transdifferentiation</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>β-galactoside</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEQhi0EomnhJ4B8QAgOC2N747VPCEW0IFXqoXC2Jt7Z1LCxg73h49_jbSLaW0-WR887r_0w9kLAOwFCv78GAN0Ya9Uba9-CgA6a7hFbCNPJRssWHrPFf-SEnZbyvV6VsvCUnQgAI42RC-au6eee4hRw5P4G44YKD5FjnTQXHy8bwcuEIYa44Wng0w3xjBNPeYNxHqxSngIf0jim3zOD2_ADfV1Af3ap7DM9Y08GHAs9P55n7Nv5p6-rz83l1cWXVS3wrRRTo40G7HurSFmSZLGVZmnX2mrSLfRr4aUQNCgSfhC21b0QvV0PZJaolmhQnbHXh727nOqHyuS2oXgaR4yU9sWJrsYkmAouD6DPqZRMg9vlsMX81wlws1l3a9bN2py17tas62ru5bFgv95Sfy91UFmBV0cAi8dxyBh9KHdcJy2ouf_DAaNq41eg7IoPFD31IZOfXJ_CAy_5B7ZQlOU</recordid><startdate>19990320</startdate><enddate>19990320</enddate><creator>Bartolomé, M.Visitación</creator><creator>Vago, Philippe</creator><creator>Gil-Loyzaga, Pablo</creator><creator>Humbert, Gullienne</creator><creator>Joubert-Caron, Raymonde</creator><creator>Pujol, Rémy</creator><creator>Lenoir, Marc</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19990320</creationdate><title>Sequential changes in anti-GAL-1 staining of the rat organ of Corti following amikacin exposure</title><author>Bartolomé, M.Visitación ; Vago, Philippe ; Gil-Loyzaga, Pablo ; Humbert, Gullienne ; Joubert-Caron, Raymonde ; Pujol, Rémy ; Lenoir, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6860add93e39e2e9a42859b696e640db1c211ef3e1cf1946d11d9bfe85a35a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amikacin - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Cochlea</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Epithelial Cells - chemistry</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galectins</topic><topic>Hemagglutinins - analysis</topic><topic>Hemagglutinins - immunology</topic><topic>Hemagglutinins - metabolism</topic><topic>Lectin</topic><topic>Lectins</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Organ of Corti - cytology</topic><topic>Organ of Corti - drug effects</topic><topic>Organ of Corti - ultrastructure</topic><topic>Ototoxicity</topic><topic>Paraffin Embedding</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Transdifferentiation</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>β-galactoside</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bartolomé, M.Visitación</creatorcontrib><creatorcontrib>Vago, Philippe</creatorcontrib><creatorcontrib>Gil-Loyzaga, Pablo</creatorcontrib><creatorcontrib>Humbert, Gullienne</creatorcontrib><creatorcontrib>Joubert-Caron, Raymonde</creatorcontrib><creatorcontrib>Pujol, Rémy</creatorcontrib><creatorcontrib>Lenoir, Marc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bartolomé, M.Visitación</au><au>Vago, Philippe</au><au>Gil-Loyzaga, Pablo</au><au>Humbert, Gullienne</au><au>Joubert-Caron, Raymonde</au><au>Pujol, Rémy</au><au>Lenoir, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential changes in anti-GAL-1 staining of the rat organ of Corti following amikacin exposure</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1999-03-20</date><risdate>1999</risdate><volume>822</volume><issue>1</issue><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Hair cell loss and a non-functional epithelial reorganization appeared in the organ of Corti after acoustic or toxic damage. Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial cells. The phenotype of these atypical cells has been now investigated by using the galectine 1 (GAL-1) antibody. In the normal organ of Corti, this antibody recognizes all the epithelial cells except the sensory hair cells and their supporting cells. At PD 21, transient atypical cells were not stained by GAL-1 antibody, suggesting that they were originated from hair cells or their supporting cells. Later, the organ of Corti was substituted by an epithelial scare, GAL-1 stained. This study also emphasizes the particular resistance of the cochlear apex to degeneration after antibiotic intoxication.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10082882</pmid><doi>10.1016/S0006-8993(99)01070-7</doi><tpages>9</tpages></addata></record> |
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| subjects | Amikacin - pharmacology Animals Anti-Bacterial Agents - pharmacology Antibodies, Monoclonal Biological and medical sciences Cochlea Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Epithelial Cells - chemistry Epithelial Cells - drug effects Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology Galectins Hemagglutinins - analysis Hemagglutinins - immunology Hemagglutinins - metabolism Lectin Lectins Microscopy, Electron Microscopy, Electron, Scanning Organ of Corti - cytology Organ of Corti - drug effects Organ of Corti - ultrastructure Ototoxicity Paraffin Embedding Rat Rats Rats, Wistar Transdifferentiation Vertebrates: nervous system and sense organs β-galactoside |
| title | Sequential changes in anti-GAL-1 staining of the rat organ of Corti following amikacin exposure |
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