Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII

[Display omitted] By using a multi component reaction system (MCR), nitro acridine sulfonamides were obtained from cyclic-1,3-diketones, 4-aminobenzene sulfonamide and aromatic aldehydes. Some novel acridine bis-sulfonamides 6a–l were then synthesized by the reaction between sulfonyl chlorides and t...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-10, Vol.23 (20), p.6573-6580
Hauptverfasser:	Esirden, İbrahim, Ulus, Ramazan, Aday, Burak, Tanç, Muhammet, Supuran, Claudiu T., Kaya, Muharrem
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine Antigens, Neoplasm - metabolism Carbonic anhydrase Carbonic Anhydrase I - antagonists & inhibitors Carbonic Anhydrase I - metabolism Carbonic Anhydrase II - antagonists & inhibitors Carbonic Anhydrase II - metabolism Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrase IX Carbonic Anhydrases - metabolism Dose-Response Relationship, Drug Enzyme inhibition Humans Isoforms CA I, II, IX and VII Molecular Structure Structure-Activity Relationship Sulfonamide
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