Different skeletal regional response to continuous brain infusion of leptin in the rat

This study was designed to evaluate whether or not continuous intracerebroventricular infusion of leptin (1.5 μg/rat/24 h, for 28 days) produced different regional response on the skeleton of growing rats. Leptin reduce the accretion of total femoral bone mineral content (BMC) and density (BMD). Thi...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-06, Vol.27 (6), p.1426-1433
Hauptverfasser:	Guidobono, F., Pagani, F., Sibilia, V., Netti, C., Lattuada, N., Rapetti, D., Mrak, E., Villa, I., Cavani, F., Bertoni, L., Palumbo, C., Ferretti, M., Marotti, G., Rubinacci, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Brain - metabolism Deoxypyridinoline DXA Fundamental and applied biological sciences. Psychology Leptin Leptin - administration & dosage Leptin - metabolism Male Osteocalcin Osteocalcin - blood Peptides - chemistry Planar bone mineral density pQCT Rats Rats, Sprague-Dawley Time Factors Tomography, X-Ray Computed Vertebrates: endocrinology Volumetric bone mineral density
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