Ganglioside changes in brain in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat
Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. Rats were sacrificed at different phases of the disease (just before the onset of c...
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| Veröffentlicht in: | Neurochemical research 1998-11, Vol.23 (11), p.1421-1425 |
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| creator | ZAPRIANOVA, E DELEVA, D FILCHEV, A |
| description | Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. Rats were sacrificed at different phases of the disease (just before the onset of clinical signs, during the first clinical episode of CREAE and during the first recovery). Gangliosides were extracted from the brain, analysed after purification by HPTLC fractionation and quantified densitometrically. An increase of GM1, the main rat myelin ganglioside, and a decrease of GT1b, suggested to play a role in mediating the interactions between oligodendroglia and axons, were observed during the development of the CREAE. These findings indicating significant ganglioside changes in CREAE give further support to the concept concerning the involvement of gangliosides in autoimmune demyelination. |
| doi_str_mv | 10.1023/A:1020758908579 |
| format | Article |
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Rats were sacrificed at different phases of the disease (just before the onset of clinical signs, during the first clinical episode of CREAE and during the first recovery). Gangliosides were extracted from the brain, analysed after purification by HPTLC fractionation and quantified densitometrically. An increase of GM1, the main rat myelin ganglioside, and a decrease of GT1b, suggested to play a role in mediating the interactions between oligodendroglia and axons, were observed during the development of the CREAE. These findings indicating significant ganglioside changes in CREAE give further support to the concept concerning the involvement of gangliosides in autoimmune demyelination.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1023/A:1020758908579</identifier><identifier>PMID: 9814553</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Autoimmune diseases ; Biological and medical sciences ; Brain - metabolism ; Chronic Disease ; Cyclosporine - therapeutic use ; Dose-Response Relationship, Drug ; Encephalomyelitis, Autoimmune, Experimental - chemically induced ; Encephalomyelitis, Autoimmune, Experimental - metabolism ; Freund's Adjuvant ; Gangliosides - metabolism ; Immunosuppressive Agents - therapeutic use ; Medical sciences ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Myelin Sheath - physiology ; Neurology ; Rats ; Rats, Inbred Lew ; Recurrence</subject><ispartof>Neurochemical research, 1998-11, Vol.23 (11), p.1421-1425</ispartof><rights>1998 INIST-CNRS</rights><rights>Plenum Publishing Corporation 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2438707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9814553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAPRIANOVA, E</creatorcontrib><creatorcontrib>DELEVA, D</creatorcontrib><creatorcontrib>FILCHEV, A</creatorcontrib><title>Ganglioside changes in brain in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. Rats were sacrificed at different phases of the disease (just before the onset of clinical signs, during the first clinical episode of CREAE and during the first recovery). Gangliosides were extracted from the brain, analysed after purification by HPTLC fractionation and quantified densitometrically. An increase of GM1, the main rat myelin ganglioside, and a decrease of GT1b, suggested to play a role in mediating the interactions between oligodendroglia and axons, were observed during the development of the CREAE. These findings indicating significant ganglioside changes in CREAE give further support to the concept concerning the involvement of gangliosides in autoimmune demyelination.</description><subject>Animals</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Chronic Disease</subject><subject>Cyclosporine - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Encephalomyelitis, Autoimmune, Experimental - chemically induced</subject><subject>Encephalomyelitis, Autoimmune, Experimental - metabolism</subject><subject>Freund's Adjuvant</subject><subject>Gangliosides - metabolism</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Medical sciences</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Myelin Sheath - physiology</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Recurrence</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdUE1r3DAQFaUh2aY991QwtPTmdKSRLSu3EPJRWMglPRutNN5V0MqOZNPk31dLlxwCwwwz781j5jH2lcMFB4G_ri5LAdV0GrpG6Q9sxRuFdasBP7IVYCtr5BrO2KecnwA4gOCn7FR3XDYNrli6M3Eb_Ji9o8ruSkO58rHaJFNyCbtLY_S2ShTMlH3cVvQyUfJ7irMJlQmB0rbgFC1NOxPG_SsFP_uDilssuYPIvKNqTX_LMJn5MzsZTMj05VjP2Z_bm8fr-3r9cPf7-mpdT0LLudaCEFoDTg3SInLTIu-6zhmFuvyoxIDY8VZzxR24zSCpQcst2o11cpAcz9nP_7pTGp8XynO_99lSCCbSuOS-LGoQAgvx-zvi07ikWG7rOWipsEVxkPt2ZC2bPbl-Kh6Y9NofrSz4jyNusjVhSCZan99oQmKnQOE_iLeCew</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>ZAPRIANOVA, E</creator><creator>DELEVA, D</creator><creator>FILCHEV, A</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>19981101</creationdate><title>Ganglioside changes in brain in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat</title><author>ZAPRIANOVA, E ; DELEVA, D ; FILCHEV, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p294t-92e306a0d7f4c331a631888da73915772f338169171d0dbf4e53c1c3cbcd4f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Chronic Disease</topic><topic>Cyclosporine - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Encephalomyelitis, Autoimmune, Experimental - chemically induced</topic><topic>Encephalomyelitis, Autoimmune, Experimental - metabolism</topic><topic>Freund's Adjuvant</topic><topic>Gangliosides - metabolism</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Medical sciences</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. 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| subjects | Animals Autoimmune diseases Biological and medical sciences Brain - metabolism Chronic Disease Cyclosporine - therapeutic use Dose-Response Relationship, Drug Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - metabolism Freund's Adjuvant Gangliosides - metabolism Immunosuppressive Agents - therapeutic use Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Sheath - physiology Neurology Rats Rats, Inbred Lew Recurrence |
| title | Ganglioside changes in brain in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat |
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