Local delivery of COMP-angiopoietin 1 accelerates new bone formation in rat calvarial defects

Recombinant COMP‐Ang1, a chimera of angiopoietin‐1 (Ang1) and a short coiled‐coil domain of cartilage oligomeric matrix protein (COMP), is under consideration as a therapeutic agent in bone reconstruction. However, the potential of COMP‐Ang1 to regenerate impaired bone and induce new bone formation...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2015-09, Vol.103 (9), p.2942-2951
Hauptverfasser:	Lim, Shin-Saeng, Kook, Sung-Ho, Bhattarai, Govinda, Cho, Eui-Sic, Seo, Young-Kwon, Lee, Jeong-Chae
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 - administration & dosage Animals Biocompatible Materials Biomedical materials bone regeneration Bone Regeneration - drug effects Bones calvarial defect Cartilage Oligomeric Matrix Protein - administration & dosage Collagen COMP-Ang1 Defects Drug Delivery Systems Equipment Failure Analysis Formations gene expression Male Markers Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - genetics Osteogenesis - drug effects Osteogenesis - genetics Rats Rats, Sprague-Dawley Recombinant Recombinant Fusion Proteins - administration & dosage RNA, Messenger - genetics RNA, Messenger - metabolism Scaffolds Skull - drug effects Skull - injuries Skull - physiopathology Surgery Surgical Sponges X-Ray Microtomography
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