Effects of lithium on growth, maturation, reproduction and gene expression in the nematode Caenorhabditis elegans

ABSTRACT Lithium (Li) has been widely used to treat bipolar disorder, and industrial use of Li has been increasing; thus, environmental pollution and ecological impacts of Li have become a concern. This study was conducted to clarify the potential biological effects of LiCl and Li2CO3 on a nematode,...

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Veröffentlicht in:	Journal of applied toxicology 2015-09, Vol.35 (9), p.999-1006
Hauptverfasser:	Inokuchi, Ayako, Yamamoto, Ryoko, Morita, Fumiyo, Takumi, Shota, Matsusaki, Hiromi, Ishibashi, Hiroshi, Tominaga, Nobuaki, Arizono, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animals Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - genetics Cytochromes P450 Environmental Pollutants - toxicity Gene expression Gene Expression - drug effects Genes growth Lethal Dose 50 Lithium Lithium - toxicity Lithium Carbonate - toxicity Lithium Chloride - toxicity Mathematical models Maturation microarray Nematoda Nematodes Oligonucleotide Array Sequence Analysis Reproduction Reproduction - drug effects Toxicology Transporter
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