Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering
Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) — bioactive glass (BG) composites (PLGA/BG) were m...
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| Veröffentlicht in: | Materials Science & Engineering C 2015-11, Vol.56, p.457-466 |
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| creator | Haaparanta, Anne-Marie Uppstu, Peter Hannula, Markus Ellä, Ville Rosling, Ari Kellomäki, Minna |
| description | Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) — bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.
•Novel PLGA/bioactive glass fibre composites were manufactured with freeze-drying.•Highly porous scaffolds, open pores and improved dimensional stability were achieved.•Bioactive glass fibre skeleton stabilized the degradation of freeze-dried PLGA.•The structure of the composites showed potential for tissue engineering scaffolds. |
| doi_str_mv | 10.1016/j.msec.2015.07.013 |
| format | Article |
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•Novel PLGA/bioactive glass fibre composites were manufactured with freeze-drying.•Highly porous scaffolds, open pores and improved dimensional stability were achieved.•Bioactive glass fibre skeleton stabilized the degradation of freeze-dried PLGA.•The structure of the composites showed potential for tissue engineering scaffolds.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2015.07.013</identifier><identifier>PMID: 26249615</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bioactive glass ; Biocompatibility ; Biomedical materials ; Bone ; Bone Regeneration ; Bones ; Composite ; Degradation ; Dimensional stability ; Freeze-drying ; Glass - chemistry ; Poly(d,l-lactide-co-glycolide) ; Polyglactin 910 - chemistry ; Porosity ; Scaffolds ; Three dimensional ; Tissue Engineering ; Tissue Scaffolds - chemistry</subject><ispartof>Materials Science & Engineering C, 2015-11, Vol.56, p.457-466</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-57b5a40278be35a3d9ac82cb5b6568ef134bbbebf8f08b72c524a14e0674ed5b3</citedby><cites>FETCH-LOGICAL-c503t-57b5a40278be35a3d9ac82cb5b6568ef134bbbebf8f08b72c524a14e0674ed5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2015.07.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26249615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haaparanta, Anne-Marie</creatorcontrib><creatorcontrib>Uppstu, Peter</creatorcontrib><creatorcontrib>Hannula, Markus</creatorcontrib><creatorcontrib>Ellä, Ville</creatorcontrib><creatorcontrib>Rosling, Ari</creatorcontrib><creatorcontrib>Kellomäki, Minna</creatorcontrib><title>Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) — bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.
•Novel PLGA/bioactive glass fibre composites were manufactured with freeze-drying.•Highly porous scaffolds, open pores and improved dimensional stability were achieved.•Bioactive glass fibre skeleton stabilized the degradation of freeze-dried PLGA.•The structure of the composites showed potential for tissue engineering scaffolds.</description><subject>Bioactive glass</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone</subject><subject>Bone Regeneration</subject><subject>Bones</subject><subject>Composite</subject><subject>Degradation</subject><subject>Dimensional stability</subject><subject>Freeze-drying</subject><subject>Glass - chemistry</subject><subject>Poly(d,l-lactide-co-glycolide)</subject><subject>Polyglactin 910 - chemistry</subject><subject>Porosity</subject><subject>Scaffolds</subject><subject>Three dimensional</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFvFCEYhonR2G31D3gwHOthRmCGgUm8mEZtkyZe9EyA-WZlZWAFdpv9B_5smWz1aHoiX3jeNx88CL2hpKWEDu937ZLBtoxQ3hLREto9QxsqRdcQOtLnaENGJpt-7OgFusx5R8ggO8Feogs2sH4cKN-g33fLPsUjTHhyC4TsYtAe56KN866c8IMrP7BxUdvijoC3XueMZ2cS4PwTPJQYsAt4H_3p2q_QBI2NzdafbPR1eFevUjxknK2e5-inmo4JF5fzATCErQsAyYXtK_Ri1j7D68fzCn3__OnbzW1z__XL3c3H-8Zy0pWGC8N1T5iQBjquu2nUVjJruBn4IGGmXW-MATPLmUgjmOWs17QHMogeJm66K3R97q3P_nWAXNTisgXvdYC6p6KCyrEfOBNPQMlYYSHGp6Bs4COXK8rOqE0x5wSz2ie36HRSlKjVq9qp1atavSoiVPVaQ28f-w9mgelf5K_ICnw4A1D_7uggqWwdBAuTS2CLmqL7X_8faCG26w</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Haaparanta, Anne-Marie</creator><creator>Uppstu, Peter</creator><creator>Hannula, Markus</creator><creator>Ellä, Ville</creator><creator>Rosling, Ari</creator><creator>Kellomäki, Minna</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20151101</creationdate><title>Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering</title><author>Haaparanta, Anne-Marie ; Uppstu, Peter ; Hannula, Markus ; Ellä, Ville ; Rosling, Ari ; Kellomäki, Minna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-57b5a40278be35a3d9ac82cb5b6568ef134bbbebf8f08b72c524a14e0674ed5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Bioactive glass</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bone</topic><topic>Bone Regeneration</topic><topic>Bones</topic><topic>Composite</topic><topic>Degradation</topic><topic>Dimensional stability</topic><topic>Freeze-drying</topic><topic>Glass - chemistry</topic><topic>Poly(d,l-lactide-co-glycolide)</topic><topic>Polyglactin 910 - chemistry</topic><topic>Porosity</topic><topic>Scaffolds</topic><topic>Three dimensional</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>Haaparanta, Anne-Marie</creatorcontrib><creatorcontrib>Uppstu, Peter</creatorcontrib><creatorcontrib>Hannula, Markus</creatorcontrib><creatorcontrib>Ellä, Ville</creatorcontrib><creatorcontrib>Rosling, Ari</creatorcontrib><creatorcontrib>Kellomäki, Minna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haaparanta, Anne-Marie</au><au>Uppstu, Peter</au><au>Hannula, Markus</au><au>Ellä, Ville</au><au>Rosling, Ari</au><au>Kellomäki, Minna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>56</volume><spage>457</spage><epage>466</epage><pages>457-466</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) — bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.
•Novel PLGA/bioactive glass fibre composites were manufactured with freeze-drying.•Highly porous scaffolds, open pores and improved dimensional stability were achieved.•Bioactive glass fibre skeleton stabilized the degradation of freeze-dried PLGA.•The structure of the composites showed potential for tissue engineering scaffolds.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26249615</pmid><doi>10.1016/j.msec.2015.07.013</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bioactive glass Biocompatibility Biomedical materials Bone Bone Regeneration Bones Composite Degradation Dimensional stability Freeze-drying Glass - chemistry Poly(d,l-lactide-co-glycolide) Polyglactin 910 - chemistry Porosity Scaffolds Three dimensional Tissue Engineering Tissue Scaffolds - chemistry |
| title | Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering |
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