Synthesis and biological activity of pyrimido [1, 2- a ] quinoline moiety and its 2-substituted derivatives
2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] quinoline (3). The latter were further re...
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| Veröffentlicht in: | Journal of physics. Conference series 2013-01, Vol.423 (1), p.12007-8 |
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| creator | Jadhav, A G Halikar, N K |
| description | 2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] quinoline (3). The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl group. Afforded to 3, 11-dicyano-4-imino -4H-pyrimido [1, 2-a] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities. |
| doi_str_mv | 10.1088/1742-6596/423/1/012007 |
| format | Article |
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The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl group. Afforded to 3, 11-dicyano-4-imino -4H-pyrimido [1, 2-a] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities.</description><identifier>ISSN: 1742-6588</identifier><identifier>EISSN: 1742-6596</identifier><identifier>DOI: 10.1088/1742-6596/423/1/012007</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Amines ; Aniline ; Antiinfectives and antibacterials ; Biological activity ; Catalysis ; Derivatives ; Dimethylformamide ; Malononitrile ; Methylene ; Physics ; Potassium carbonate ; Quinoline ; Spectra ; Substitutes ; Synthesis</subject><ispartof>Journal of physics. 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Conference series</title><description>2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] quinoline (3). The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl group. Afforded to 3, 11-dicyano-4-imino -4H-pyrimido [1, 2-a] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities.</description><subject>Amines</subject><subject>Aniline</subject><subject>Antiinfectives and antibacterials</subject><subject>Biological activity</subject><subject>Catalysis</subject><subject>Derivatives</subject><subject>Dimethylformamide</subject><subject>Malononitrile</subject><subject>Methylene</subject><subject>Physics</subject><subject>Potassium carbonate</subject><subject>Quinoline</subject><subject>Spectra</subject><subject>Substitutes</subject><subject>Synthesis</subject><issn>1742-6588</issn><issn>1742-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9LxDAQxYsouK5-BQl48WBtJmmT9CiL_2DBg3oSCWmaatZus9ukC_32pqzswbnMwPvNMLyXJJeAbwELkQHPScqKkmU5oRlkGAjG_CiZHYTjwyzEaXLm_QpjGovPkp_XsQvfxluPVFejyrrWfVmtWqR0sDsbRuQatBl7u7a1Qx9wg0iKFPpE28F2rrWdQWtnTeSmfRt81P1Q-WDDEEyNatPbnYqnjD9PThrVenPx1-fJ-8P92-IpXb48Pi_ulqmmLA8p11wUwjDFaq4NJVDXXFSKNCVoZUA3CqBuCk0xhqoCILwSTOU5K0mpqwLoPLne3930bjsYH-Taem3aVnXGDV4CB1HmtIQJvfqHrtzQd_E7SQrOKYWSFpFie0r3zvveNHIT_VD9KAHLKQM52Ssnq2XMQILcZ0B_AVGEedk</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Jadhav, A G</creator><creator>Halikar, N K</creator><general>IOP Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>L7M</scope><scope>P5Z</scope><scope>P62</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope></search><sort><creationdate>20130101</creationdate><title>Synthesis and biological activity of pyrimido [1, 2- a ] quinoline moiety and its 2-substituted derivatives</title><author>Jadhav, A G ; Halikar, N K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-7c7858e6a6d7ce321dd78ba2f91cae1cfa11df5c3001bb1127b86a446929cb513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amines</topic><topic>Aniline</topic><topic>Antiinfectives and antibacterials</topic><topic>Biological activity</topic><topic>Catalysis</topic><topic>Derivatives</topic><topic>Dimethylformamide</topic><topic>Malononitrile</topic><topic>Methylene</topic><topic>Physics</topic><topic>Potassium carbonate</topic><topic>Quinoline</topic><topic>Spectra</topic><topic>Substitutes</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jadhav, A G</creatorcontrib><creatorcontrib>Halikar, N K</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><jtitle>Journal of physics. Conference series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jadhav, A G</au><au>Halikar, N K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological activity of pyrimido [1, 2- a ] quinoline moiety and its 2-substituted derivatives</atitle><jtitle>Journal of physics. Conference series</jtitle><date>2013-01-01</date><risdate>2013</risdate><volume>423</volume><issue>1</issue><spage>12007</spage><epage>8</epage><pages>12007-8</pages><issn>1742-6588</issn><eissn>1742-6596</eissn><abstract>2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] quinoline (3). The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl group. Afforded to 3, 11-dicyano-4-imino -4H-pyrimido [1, 2-a] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1742-6596/423/1/012007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amines Aniline Antiinfectives and antibacterials Biological activity Catalysis Derivatives Dimethylformamide Malononitrile Methylene Physics Potassium carbonate Quinoline Spectra Substitutes Synthesis |
| title | Synthesis and biological activity of pyrimido [1, 2- a ] quinoline moiety and its 2-substituted derivatives |
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