Cyclobutane derivatives as potent NK sub(1) selective antagonists

A series of novel cyclobutane derivatives as potent and selective NK sub(1) receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (K sub(i) 1 nM), and potent inhibition of central NK sub(1) receptor following oral administration. Syntheses of th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-07, Vol.16 (14), p.3859-3863
Hauptverfasser:	Wrobleski, Michelle Laci, Reichard, Gregory A, Paliwal, Sunil, Shah, Sapna, Tsui, Hon-Chung, Duffy, Ruth A, Lachowicz, Jean E, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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