One-Pot Synthesis of Aza-Diketopiperazines Enabled by Controlled Reactivity of N‑Isocyanate Precursors

A one-pot sequence for the synthesis of aza-diketopiperazines is reported, involving carbazate acylation with chloroacetyl chloride, SN2 with a primary amine, N-isocyanate formation, and cyclization. Nitrogen-substituted isocyanates (N-isocyanates) are a rare class of amphoteric isocyanate with high...

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Veröffentlicht in:	Organic letters 2015-10, Vol.17 (19), p.4898-4901
Hauptverfasser:	Ivanovich, Ryan A, Vincent-Rocan, Jean-François, Elkaeed, Eslam B, Beauchemin, André M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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