SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis
BACKGROUND/OBJECTIVERecently, a genome-wide association study showed a statistically significant association between the rs3794087 single nucleotide polymorphism (SNP) in the solute carrier family 1 – glial affinity glutamate transporter, member 2 (SLC1A2) and the risk for essential tremor (ET). How...
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| Veröffentlicht in: | Pharmacogenetics and genomics 2015-11, Vol.25 (11), p.564-568 |
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| creator | Jiménez-Jiménez, Félix J Alonso-Navarro, Hortensia García-Martín, Elena Agúndez, José A.G |
| description | BACKGROUND/OBJECTIVERecently, a genome-wide association study showed a statistically significant association between the rs3794087 single nucleotide polymorphism (SNP) in the solute carrier family 1 – glial affinity glutamate transporter, member 2 (SLC1A2) and the risk for essential tremor (ET). However, four further association studies showed controversial results.We carried out a systematic review and a meta-analysis including all the studies published on the risk of ET related to this SNP.
MATERIALS AND METHODSThe systematic review was performed using several databases, the meta-analysis was carried out using the software Meta-DiSc 1.1.1, and heterogeneity between studies was tested using the Q statistic.
RESULTSThe meta-analysis included five association studies for the SLC1A2 rs3794087 SNP (1925 ET patients, 4914 controls) and the risk for ET. The global diagnostic odds ratio (95% confidence intervals) was 1.08 (0.79–1.48) for the total group. After excluding data from the discovery series (which was responsible for a high degree of heterogeneity), the global diagnostic odds ratio (95% confidence intervals) was 0.96 (0.74–1.23). The separate analysis in White and Asiatic individuals on the frequency of the minor allele of rs3794087 did not show significant differences between ET patients and controls in both subgroups after excluding the discovery series.
CONCLUSIONThe results of the meta-analysis suggest that rs3794087 is not associated with the risk for ET. |
| doi_str_mv | 10.1097/FPC.0000000000000171 |
| format | Article |
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MATERIALS AND METHODSThe systematic review was performed using several databases, the meta-analysis was carried out using the software Meta-DiSc 1.1.1, and heterogeneity between studies was tested using the Q statistic.
RESULTSThe meta-analysis included five association studies for the SLC1A2 rs3794087 SNP (1925 ET patients, 4914 controls) and the risk for ET. The global diagnostic odds ratio (95% confidence intervals) was 1.08 (0.79–1.48) for the total group. After excluding data from the discovery series (which was responsible for a high degree of heterogeneity), the global diagnostic odds ratio (95% confidence intervals) was 0.96 (0.74–1.23). The separate analysis in White and Asiatic individuals on the frequency of the minor allele of rs3794087 did not show significant differences between ET patients and controls in both subgroups after excluding the discovery series.
CONCLUSIONThe results of the meta-analysis suggest that rs3794087 is not associated with the risk for ET.</description><identifier>ISSN: 1744-6872</identifier><identifier>EISSN: 1744-6880</identifier><identifier>DOI: 10.1097/FPC.0000000000000171</identifier><identifier>PMID: 26313486</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Essential Tremor - genetics ; European Continental Ancestry Group - genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Glutamate Plasma Membrane Transport Proteins - genetics ; Humans ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors</subject><ispartof>Pharmacogenetics and genomics, 2015-11, Vol.25 (11), p.564-568</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3051-66fa9b6b84fc2858117ad5a2f756de3294601d1cfa5f724230d0c8dbe02be3743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26313486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiménez-Jiménez, Félix J</creatorcontrib><creatorcontrib>Alonso-Navarro, Hortensia</creatorcontrib><creatorcontrib>García-Martín, Elena</creatorcontrib><creatorcontrib>Agúndez, José A.G</creatorcontrib><title>SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis</title><title>Pharmacogenetics and genomics</title><addtitle>Pharmacogenet Genomics</addtitle><description>BACKGROUND/OBJECTIVERecently, a genome-wide association study showed a statistically significant association between the rs3794087 single nucleotide polymorphism (SNP) in the solute carrier family 1 – glial affinity glutamate transporter, member 2 (SLC1A2) and the risk for essential tremor (ET). However, four further association studies showed controversial results.We carried out a systematic review and a meta-analysis including all the studies published on the risk of ET related to this SNP.
MATERIALS AND METHODSThe systematic review was performed using several databases, the meta-analysis was carried out using the software Meta-DiSc 1.1.1, and heterogeneity between studies was tested using the Q statistic.
RESULTSThe meta-analysis included five association studies for the SLC1A2 rs3794087 SNP (1925 ET patients, 4914 controls) and the risk for ET. The global diagnostic odds ratio (95% confidence intervals) was 1.08 (0.79–1.48) for the total group. After excluding data from the discovery series (which was responsible for a high degree of heterogeneity), the global diagnostic odds ratio (95% confidence intervals) was 0.96 (0.74–1.23). The separate analysis in White and Asiatic individuals on the frequency of the minor allele of rs3794087 did not show significant differences between ET patients and controls in both subgroups after excluding the discovery series.
CONCLUSIONThe results of the meta-analysis suggest that rs3794087 is not associated with the risk for ET.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Case-Control Studies</subject><subject>Essential Tremor - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Glutamate Plasma Membrane Transport Proteins - genetics</subject><subject>Humans</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><issn>1744-6872</issn><issn>1744-6880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxEAQRRtRfP-BSC_dRPuV7o47GXzBgIK6lFBJKhjNQ7t6Zpi_Nzoq4sLaVC3OvQWHsQMpjqXI3MnF7eRY_B7p5Brbls6YxHov1n9up7bYDtGzENpmRm2yLWW11MbbbfZ4N53IM8UDaZcZ4R2fQ2igjxz6ioeGXng9BI5E2McGWh4DdkM45cBpSRE7iE3JA84bXHxGOoyQQA_tkhraYxs1tIT7X3uXPVyc30-ukunN5fXkbJqUWqQysbaGrLCFN3WpfOqldFCloGqX2gq1yowVspJlDWntlFFaVKL0VYFCFaid0bvsaNX7Goa3GVLMu4ZKbFvocZhRPqrxmVTa2RE1K7QMA1HAOn8NTQdhmUuRf4jNR7H5X7Fj7PDrw6zosPoJfZscAb8CFkMbMdBLO1tgyJ8Q2vj0f_c7thOClw</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Jiménez-Jiménez, Félix J</creator><creator>Alonso-Navarro, Hortensia</creator><creator>García-Martín, Elena</creator><creator>Agúndez, José A.G</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis</title><author>Jiménez-Jiménez, Félix J ; Alonso-Navarro, Hortensia ; García-Martín, Elena ; Agúndez, José A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3051-66fa9b6b84fc2858117ad5a2f756de3294601d1cfa5f724230d0c8dbe02be3743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Case-Control Studies</topic><topic>Essential Tremor - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Glutamate Plasma Membrane Transport Proteins - genetics</topic><topic>Humans</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiménez-Jiménez, Félix J</creatorcontrib><creatorcontrib>Alonso-Navarro, Hortensia</creatorcontrib><creatorcontrib>García-Martín, Elena</creatorcontrib><creatorcontrib>Agúndez, José A.G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenetics and genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiménez-Jiménez, Félix J</au><au>Alonso-Navarro, Hortensia</au><au>García-Martín, Elena</au><au>Agúndez, José A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis</atitle><jtitle>Pharmacogenetics and genomics</jtitle><addtitle>Pharmacogenet Genomics</addtitle><date>2015-11</date><risdate>2015</risdate><volume>25</volume><issue>11</issue><spage>564</spage><epage>568</epage><pages>564-568</pages><issn>1744-6872</issn><eissn>1744-6880</eissn><abstract>BACKGROUND/OBJECTIVERecently, a genome-wide association study showed a statistically significant association between the rs3794087 single nucleotide polymorphism (SNP) in the solute carrier family 1 – glial affinity glutamate transporter, member 2 (SLC1A2) and the risk for essential tremor (ET). However, four further association studies showed controversial results.We carried out a systematic review and a meta-analysis including all the studies published on the risk of ET related to this SNP.
MATERIALS AND METHODSThe systematic review was performed using several databases, the meta-analysis was carried out using the software Meta-DiSc 1.1.1, and heterogeneity between studies was tested using the Q statistic.
RESULTSThe meta-analysis included five association studies for the SLC1A2 rs3794087 SNP (1925 ET patients, 4914 controls) and the risk for ET. The global diagnostic odds ratio (95% confidence intervals) was 1.08 (0.79–1.48) for the total group. After excluding data from the discovery series (which was responsible for a high degree of heterogeneity), the global diagnostic odds ratio (95% confidence intervals) was 0.96 (0.74–1.23). The separate analysis in White and Asiatic individuals on the frequency of the minor allele of rs3794087 did not show significant differences between ET patients and controls in both subgroups after excluding the discovery series.
CONCLUSIONThe results of the meta-analysis suggest that rs3794087 is not associated with the risk for ET.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26313486</pmid><doi>10.1097/FPC.0000000000000171</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Asian Continental Ancestry Group - genetics Case-Control Studies Essential Tremor - genetics European Continental Ancestry Group - genetics Gene Frequency Genetic Predisposition to Disease Genome-Wide Association Study Glutamate Plasma Membrane Transport Proteins - genetics Humans Odds Ratio Polymorphism, Single Nucleotide Risk Factors |
| title | SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis |
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