Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes
In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP level...
Gespeichert in:
| Veröffentlicht in: | Journal of hypertension 2015-10, Vol.33 (10), p.2091-2098 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2098 |
|---|---|
| container_issue | 10 |
| container_start_page | 2091 |
| container_title | Journal of hypertension |
| container_volume | 33 |
| creator | Walraven, Iris Mast, M Ruth Hoekstra, Trynke Jansen, Aaltje P D Rauh, Simone P Rutters, Femke R van der Heijden, Amber A W A Elders, Petra J M Moll, Annette C Polak, Bettine C P Dekker, Jacqueline M Nijpels, Giel |
| description | In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patients and its associated consequences. Subgroup characteristics were determined and the prevalence of complications and mortality rates over time in the different subgroups was investigated.
Five thousand, seven hundred and eleven T2DM patients with at least two SBP follow-up measurements were selected from a prospective T2DM cohort of 9849 T2DM patients. The mean follow-up period was 5.7 years (range 2-9 years). Latent Class Growth Modeling, as currently the most flexible cluster analysis available, was performed to identify subgroups of patients with distinct SBP trajectories. Subgroup characteristics were determined by multinomial logistic regression analyses.
Four subgroups with distinct SBP trajectories were identified. The largest subgroup (85.6%) showed adequate SBP control (at or around 140 mmHg) over time. The second subgroup (5.6%) were hypertensive in the first years, responded slowly to BP management and eventually reached SBP control. The third subgroup (3.4%) showed deteriorating hypertension during the first 4 years, then showed insufficient response to BP management. The fourth subgroup (5.4%) showed deteriorating hypertension over time. Patients within subgroups 2-4 were significantly older, comprised more women, used more antihypertensive medication and had a higher prevalence of retinopathy, microalbuminuria and cardiovascular disease (CVD) mortality.
More than 85% reached and maintained adequate SBP control. Subgroups with a more unfavourable course of SBP control also showed higher rates of microvascular complications and CVD mortality over time. This study identified important subgroups to target in order to improve BP management in T2DM patients. |
| doi_str_mv | 10.1097/HJH.0000000000000680 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1718909994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718909994</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-89c8cb10fd496a81fb3bc543cc64a0b9b80ea3c3c387959f70479c5caa49c1933</originalsourceid><addsrcrecordid>eNpdkMFKxDAQhoMo7rr6BiI5eumaNGmTHGVRV1kQRA-eSpJOsZJtapK67Ntb2VXEmcNcvn-G-RA6p2ROiRJXy4flnPytUpIDNKVcsKwolDxEU5KXLCtZkU_QSYzvIyOVYMdokpc5E0VJpuj1CbTLNj64GsNnW0NnAfsGx8H4PrVr7bBx3te4DxDjEABb36XgHW473OvUQpci3rTpDadtDzjHdasNJIin6KjRLsLZfs7Qy-3N82KZrR7v7hfXq8wyIlImlZXWUNLUXJVa0sYwYwvOrC25JkYZSUAzO7YUqlCNIFwoW1itubJUMTZDl7u9ffAfA8RUrdtowTndgR9iRQWViiil-IjyHWqDjzFAU_VhfDFsK0qqb6nVKLX6L3WMXewvDGYN9W_oxyL7Al6_crA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1718909994</pqid></control><display><type>article</type><title>Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Walraven, Iris ; Mast, M Ruth ; Hoekstra, Trynke ; Jansen, Aaltje P D ; Rauh, Simone P ; Rutters, Femke R ; van der Heijden, Amber A W A ; Elders, Petra J M ; Moll, Annette C ; Polak, Bettine C P ; Dekker, Jacqueline M ; Nijpels, Giel</creator><creatorcontrib>Walraven, Iris ; Mast, M Ruth ; Hoekstra, Trynke ; Jansen, Aaltje P D ; Rauh, Simone P ; Rutters, Femke R ; van der Heijden, Amber A W A ; Elders, Petra J M ; Moll, Annette C ; Polak, Bettine C P ; Dekker, Jacqueline M ; Nijpels, Giel</creatorcontrib><description>In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patients and its associated consequences. Subgroup characteristics were determined and the prevalence of complications and mortality rates over time in the different subgroups was investigated.
Five thousand, seven hundred and eleven T2DM patients with at least two SBP follow-up measurements were selected from a prospective T2DM cohort of 9849 T2DM patients. The mean follow-up period was 5.7 years (range 2-9 years). Latent Class Growth Modeling, as currently the most flexible cluster analysis available, was performed to identify subgroups of patients with distinct SBP trajectories. Subgroup characteristics were determined by multinomial logistic regression analyses.
Four subgroups with distinct SBP trajectories were identified. The largest subgroup (85.6%) showed adequate SBP control (at or around 140 mmHg) over time. The second subgroup (5.6%) were hypertensive in the first years, responded slowly to BP management and eventually reached SBP control. The third subgroup (3.4%) showed deteriorating hypertension during the first 4 years, then showed insufficient response to BP management. The fourth subgroup (5.4%) showed deteriorating hypertension over time. Patients within subgroups 2-4 were significantly older, comprised more women, used more antihypertensive medication and had a higher prevalence of retinopathy, microalbuminuria and cardiovascular disease (CVD) mortality.
More than 85% reached and maintained adequate SBP control. Subgroups with a more unfavourable course of SBP control also showed higher rates of microvascular complications and CVD mortality over time. This study identified important subgroups to target in order to improve BP management in T2DM patients.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0000000000000680</identifier><identifier>PMID: 26237560</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Age Factors ; Aged ; Albuminuria - epidemiology ; Antihypertensive Agents - therapeutic use ; Blood Pressure - drug effects ; Cardiovascular Diseases - mortality ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Retinopathy - epidemiology ; Female ; Follow-Up Studies ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertensive Retinopathy - epidemiology ; Male ; Middle Aged ; Netherlands - epidemiology ; Prevalence ; Prospective Studies ; Sex Factors ; Systole</subject><ispartof>Journal of hypertension, 2015-10, Vol.33 (10), p.2091-2098</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-89c8cb10fd496a81fb3bc543cc64a0b9b80ea3c3c387959f70479c5caa49c1933</citedby><cites>FETCH-LOGICAL-c307t-89c8cb10fd496a81fb3bc543cc64a0b9b80ea3c3c387959f70479c5caa49c1933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26237560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walraven, Iris</creatorcontrib><creatorcontrib>Mast, M Ruth</creatorcontrib><creatorcontrib>Hoekstra, Trynke</creatorcontrib><creatorcontrib>Jansen, Aaltje P D</creatorcontrib><creatorcontrib>Rauh, Simone P</creatorcontrib><creatorcontrib>Rutters, Femke R</creatorcontrib><creatorcontrib>van der Heijden, Amber A W A</creatorcontrib><creatorcontrib>Elders, Petra J M</creatorcontrib><creatorcontrib>Moll, Annette C</creatorcontrib><creatorcontrib>Polak, Bettine C P</creatorcontrib><creatorcontrib>Dekker, Jacqueline M</creatorcontrib><creatorcontrib>Nijpels, Giel</creatorcontrib><title>Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patients and its associated consequences. Subgroup characteristics were determined and the prevalence of complications and mortality rates over time in the different subgroups was investigated.
Five thousand, seven hundred and eleven T2DM patients with at least two SBP follow-up measurements were selected from a prospective T2DM cohort of 9849 T2DM patients. The mean follow-up period was 5.7 years (range 2-9 years). Latent Class Growth Modeling, as currently the most flexible cluster analysis available, was performed to identify subgroups of patients with distinct SBP trajectories. Subgroup characteristics were determined by multinomial logistic regression analyses.
Four subgroups with distinct SBP trajectories were identified. The largest subgroup (85.6%) showed adequate SBP control (at or around 140 mmHg) over time. The second subgroup (5.6%) were hypertensive in the first years, responded slowly to BP management and eventually reached SBP control. The third subgroup (3.4%) showed deteriorating hypertension during the first 4 years, then showed insufficient response to BP management. The fourth subgroup (5.4%) showed deteriorating hypertension over time. Patients within subgroups 2-4 were significantly older, comprised more women, used more antihypertensive medication and had a higher prevalence of retinopathy, microalbuminuria and cardiovascular disease (CVD) mortality.
More than 85% reached and maintained adequate SBP control. Subgroups with a more unfavourable course of SBP control also showed higher rates of microvascular complications and CVD mortality over time. This study identified important subgroups to target in order to improve BP management in T2DM patients.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Albuminuria - epidemiology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertensive Retinopathy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Sex Factors</subject><subject>Systole</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMFKxDAQhoMo7rr6BiI5eumaNGmTHGVRV1kQRA-eSpJOsZJtapK67Ntb2VXEmcNcvn-G-RA6p2ROiRJXy4flnPytUpIDNKVcsKwolDxEU5KXLCtZkU_QSYzvIyOVYMdokpc5E0VJpuj1CbTLNj64GsNnW0NnAfsGx8H4PrVr7bBx3te4DxDjEABb36XgHW473OvUQpci3rTpDadtDzjHdasNJIin6KjRLsLZfs7Qy-3N82KZrR7v7hfXq8wyIlImlZXWUNLUXJVa0sYwYwvOrC25JkYZSUAzO7YUqlCNIFwoW1itubJUMTZDl7u9ffAfA8RUrdtowTndgR9iRQWViiil-IjyHWqDjzFAU_VhfDFsK0qqb6nVKLX6L3WMXewvDGYN9W_oxyL7Al6_crA</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Walraven, Iris</creator><creator>Mast, M Ruth</creator><creator>Hoekstra, Trynke</creator><creator>Jansen, Aaltje P D</creator><creator>Rauh, Simone P</creator><creator>Rutters, Femke R</creator><creator>van der Heijden, Amber A W A</creator><creator>Elders, Petra J M</creator><creator>Moll, Annette C</creator><creator>Polak, Bettine C P</creator><creator>Dekker, Jacqueline M</creator><creator>Nijpels, Giel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes</title><author>Walraven, Iris ; Mast, M Ruth ; Hoekstra, Trynke ; Jansen, Aaltje P D ; Rauh, Simone P ; Rutters, Femke R ; van der Heijden, Amber A W A ; Elders, Petra J M ; Moll, Annette C ; Polak, Bettine C P ; Dekker, Jacqueline M ; Nijpels, Giel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-89c8cb10fd496a81fb3bc543cc64a0b9b80ea3c3c387959f70479c5caa49c1933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Albuminuria - epidemiology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertensive Retinopathy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Sex Factors</topic><topic>Systole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walraven, Iris</creatorcontrib><creatorcontrib>Mast, M Ruth</creatorcontrib><creatorcontrib>Hoekstra, Trynke</creatorcontrib><creatorcontrib>Jansen, Aaltje P D</creatorcontrib><creatorcontrib>Rauh, Simone P</creatorcontrib><creatorcontrib>Rutters, Femke R</creatorcontrib><creatorcontrib>van der Heijden, Amber A W A</creatorcontrib><creatorcontrib>Elders, Petra J M</creatorcontrib><creatorcontrib>Moll, Annette C</creatorcontrib><creatorcontrib>Polak, Bettine C P</creatorcontrib><creatorcontrib>Dekker, Jacqueline M</creatorcontrib><creatorcontrib>Nijpels, Giel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walraven, Iris</au><au>Mast, M Ruth</au><au>Hoekstra, Trynke</au><au>Jansen, Aaltje P D</au><au>Rauh, Simone P</au><au>Rutters, Femke R</au><au>van der Heijden, Amber A W A</au><au>Elders, Petra J M</au><au>Moll, Annette C</au><au>Polak, Bettine C P</au><au>Dekker, Jacqueline M</au><au>Nijpels, Giel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>33</volume><issue>10</issue><spage>2091</spage><epage>2098</epage><pages>2091-2098</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><abstract>In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patients and its associated consequences. Subgroup characteristics were determined and the prevalence of complications and mortality rates over time in the different subgroups was investigated.
Five thousand, seven hundred and eleven T2DM patients with at least two SBP follow-up measurements were selected from a prospective T2DM cohort of 9849 T2DM patients. The mean follow-up period was 5.7 years (range 2-9 years). Latent Class Growth Modeling, as currently the most flexible cluster analysis available, was performed to identify subgroups of patients with distinct SBP trajectories. Subgroup characteristics were determined by multinomial logistic regression analyses.
Four subgroups with distinct SBP trajectories were identified. The largest subgroup (85.6%) showed adequate SBP control (at or around 140 mmHg) over time. The second subgroup (5.6%) were hypertensive in the first years, responded slowly to BP management and eventually reached SBP control. The third subgroup (3.4%) showed deteriorating hypertension during the first 4 years, then showed insufficient response to BP management. The fourth subgroup (5.4%) showed deteriorating hypertension over time. Patients within subgroups 2-4 were significantly older, comprised more women, used more antihypertensive medication and had a higher prevalence of retinopathy, microalbuminuria and cardiovascular disease (CVD) mortality.
More than 85% reached and maintained adequate SBP control. Subgroups with a more unfavourable course of SBP control also showed higher rates of microvascular complications and CVD mortality over time. This study identified important subgroups to target in order to improve BP management in T2DM patients.</abstract><cop>England</cop><pmid>26237560</pmid><doi>10.1097/HJH.0000000000000680</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0263-6352 |
| ispartof | Journal of hypertension, 2015-10, Vol.33 (10), p.2091-2098 |
| issn | 0263-6352 1473-5598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1718909994 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Age Factors Aged Albuminuria - epidemiology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Cardiovascular Diseases - mortality Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetic Retinopathy - epidemiology Female Follow-Up Studies Humans Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Hypertensive Retinopathy - epidemiology Male Middle Aged Netherlands - epidemiology Prevalence Prospective Studies Sex Factors Systole |
| title | Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T06%3A45%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Real-world%20evidence%20of%20suboptimal%20blood%20pressure%20control%20in%20patients%20with%20type%202%20diabetes&rft.jtitle=Journal%20of%20hypertension&rft.au=Walraven,%20Iris&rft.date=2015-10-01&rft.volume=33&rft.issue=10&rft.spage=2091&rft.epage=2098&rft.pages=2091-2098&rft.issn=0263-6352&rft.eissn=1473-5598&rft_id=info:doi/10.1097/HJH.0000000000000680&rft_dat=%3Cproquest_cross%3E1718909994%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1718909994&rft_id=info:pmid/26237560&rfr_iscdi=true |