Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure
A 28-year-old man was referred to our hospital for the treatment of congestive heart failure and severe hypertension. The patient was diagnosed with malignant phase hypertension based on the presence of marked hypertension with left ventricular hypertrophy, exudate retinopathy, and renal failure. In...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(19), pp.2467-2470 |
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| creator | Takahashi, Fumihiko Goto, Masahide Wada, Yoshiki Hasebe, Naoyuki |
| description | A 28-year-old man was referred to our hospital for the treatment of congestive heart failure and severe hypertension. The patient was diagnosed with malignant phase hypertension based on the presence of marked hypertension with left ventricular hypertrophy, exudate retinopathy, and renal failure. Intensive therapy for hypertension and heart failure with a combination of antihypertensive drugs including nitroglycerin, nifedipine, eplerenone and candesartan successfully lowered his blood pressure and further improved the renal function. Eplerenone could be one of the choices of antihypertensive drugs in combination therapy in patients with malignant phase hypertension with progressive heart and renal failure. |
| doi_str_mv | 10.2169/internalmedicine.54.4425 |
| format | Article |
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The patient was diagnosed with malignant phase hypertension based on the presence of marked hypertension with left ventricular hypertrophy, exudate retinopathy, and renal failure. Intensive therapy for hypertension and heart failure with a combination of antihypertensive drugs including nitroglycerin, nifedipine, eplerenone and candesartan successfully lowered his blood pressure and further improved the renal function. Eplerenone could be one of the choices of antihypertensive drugs in combination therapy in patients with malignant phase hypertension with progressive heart and renal failure.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.4425</identifier><identifier>PMID: 26424305</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject><![CDATA[Adrenergic beta-Antagonists - administration & dosage ; Adult ; Antihypertensive Agents - administration & dosage ; Benzimidazoles - administration & dosage ; Calcium Channel Blockers - administration & dosage ; Creatinine - blood ; Drug Therapy, Combination ; eplerenone ; Heart Failure - complications ; Heart Failure - drug therapy ; Heart Failure - physiopathology ; Humans ; Hypertension, Malignant - drug therapy ; Hypertension, Malignant - pathology ; hypertensive emergency ; Male ; Nifedipine - administration & dosage ; Nitroglycerin - administration & dosage ; Obesity - blood ; Obesity - complications ; Obesity - physiopathology ; Renal Insufficiency - blood ; Renal Insufficiency - drug therapy ; Renal Insufficiency - prevention & control ; renin-angiotensin-aldosterone system ; Spironolactone - administration & dosage ; Spironolactone - analogs & derivatives ; Tetrazoles - administration & dosage ; Treatment Outcome ; Vasodilator Agents - administration & dosage]]></subject><ispartof>Internal Medicine, 2015, Vol.54(19), pp.2467-2470</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-c76a5aa46f7f3adb30bda03b6e5755198fd70f224d81d18593c4fe4cbbb1c1783</citedby><cites>FETCH-LOGICAL-c527t-c76a5aa46f7f3adb30bda03b6e5755198fd70f224d81d18593c4fe4cbbb1c1783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26424305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Fumihiko</creatorcontrib><creatorcontrib>Goto, Masahide</creatorcontrib><creatorcontrib>Wada, Yoshiki</creatorcontrib><creatorcontrib>Hasebe, Naoyuki</creatorcontrib><title>Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 28-year-old man was referred to our hospital for the treatment of congestive heart failure and severe hypertension. The patient was diagnosed with malignant phase hypertension based on the presence of marked hypertension with left ventricular hypertrophy, exudate retinopathy, and renal failure. Intensive therapy for hypertension and heart failure with a combination of antihypertensive drugs including nitroglycerin, nifedipine, eplerenone and candesartan successfully lowered his blood pressure and further improved the renal function. Eplerenone could be one of the choices of antihypertensive drugs in combination therapy in patients with malignant phase hypertension with progressive heart and renal failure.</description><subject>Adrenergic beta-Antagonists - administration & dosage</subject><subject>Adult</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Benzimidazoles - administration & dosage</subject><subject>Calcium Channel Blockers - administration & dosage</subject><subject>Creatinine - blood</subject><subject>Drug Therapy, Combination</subject><subject>eplerenone</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Hypertension, Malignant - drug therapy</subject><subject>Hypertension, Malignant - pathology</subject><subject>hypertensive emergency</subject><subject>Male</subject><subject>Nifedipine - administration & dosage</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Renal Insufficiency - blood</subject><subject>Renal Insufficiency - drug therapy</subject><subject>Renal Insufficiency - prevention & control</subject><subject>renin-angiotensin-aldosterone system</subject><subject>Spironolactone - administration & dosage</subject><subject>Spironolactone - analogs & derivatives</subject><subject>Tetrazoles - administration & dosage</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9u1DAQxi0EokvhFZCPXLL4b-Icq9LSSkWtSjlHE2eSdeV1Ftsp6mPwxmS1Sw5VLzMazW--T6OPEMrZWvCy_upCxhjAb7Fz1gVca7VWSug3ZMWlqotKSP2WrFjNTSHmckI-pPTImDRVLd6TE1EqoSTTK_L352QtptRPnj5EhLzFkOkflzcUAj0L2W2edxgzhuSekH6L00DvcXAzRq-D9VPnwkAvdh4jhjEgdYECvYPsFp0f4N0QYB7vNpCQXi2CYzgQ9zj_Qi_B-SniR_KuB5_w07Gfkl-XFw_nV8XN7ffr87ObwmpR5cJWJWgAVfZVL6FrJWs7YLItUVda89r0XcV6IVRneMeNrqVVPSrbti23vDLylHw56O7i-HvClJutSxa9h4DjlBpecVMzY-pyRs0BtXFMKWLf7KLbQnxuOGv2gTQvA2m0avaBzKefjy5TOy-Xw_8JzMDtAXhMGQZcAIjZWY-vKvN6X48WC2k3EBsM8h-w8q1g</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Takahashi, Fumihiko</creator><creator>Goto, Masahide</creator><creator>Wada, Yoshiki</creator><creator>Hasebe, Naoyuki</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure</title><author>Takahashi, Fumihiko ; Goto, Masahide ; Wada, Yoshiki ; Hasebe, Naoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-c76a5aa46f7f3adb30bda03b6e5755198fd70f224d81d18593c4fe4cbbb1c1783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adrenergic beta-Antagonists - administration & dosage</topic><topic>Adult</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Benzimidazoles - administration & dosage</topic><topic>Calcium Channel Blockers - administration & dosage</topic><topic>Creatinine - blood</topic><topic>Drug Therapy, Combination</topic><topic>eplerenone</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Hypertension, Malignant - drug therapy</topic><topic>Hypertension, Malignant - pathology</topic><topic>hypertensive emergency</topic><topic>Male</topic><topic>Nifedipine - administration & dosage</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Renal Insufficiency - blood</topic><topic>Renal Insufficiency - drug therapy</topic><topic>Renal Insufficiency - prevention & control</topic><topic>renin-angiotensin-aldosterone system</topic><topic>Spironolactone - administration & dosage</topic><topic>Spironolactone - analogs & derivatives</topic><topic>Tetrazoles - administration & dosage</topic><topic>Treatment Outcome</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Fumihiko</creatorcontrib><creatorcontrib>Goto, Masahide</creatorcontrib><creatorcontrib>Wada, Yoshiki</creatorcontrib><creatorcontrib>Hasebe, Naoyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Fumihiko</au><au>Goto, Masahide</au><au>Wada, Yoshiki</au><au>Hasebe, Naoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>19</issue><spage>2467</spage><epage>2470</epage><pages>2467-2470</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 28-year-old man was referred to our hospital for the treatment of congestive heart failure and severe hypertension. The patient was diagnosed with malignant phase hypertension based on the presence of marked hypertension with left ventricular hypertrophy, exudate retinopathy, and renal failure. Intensive therapy for hypertension and heart failure with a combination of antihypertensive drugs including nitroglycerin, nifedipine, eplerenone and candesartan successfully lowered his blood pressure and further improved the renal function. Eplerenone could be one of the choices of antihypertensive drugs in combination therapy in patients with malignant phase hypertension with progressive heart and renal failure.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>26424305</pmid><doi>10.2169/internalmedicine.54.4425</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adrenergic beta-Antagonists - administration & dosage Adult Antihypertensive Agents - administration & dosage Benzimidazoles - administration & dosage Calcium Channel Blockers - administration & dosage Creatinine - blood Drug Therapy, Combination eplerenone Heart Failure - complications Heart Failure - drug therapy Heart Failure - physiopathology Humans Hypertension, Malignant - drug therapy Hypertension, Malignant - pathology hypertensive emergency Male Nifedipine - administration & dosage Nitroglycerin - administration & dosage Obesity - blood Obesity - complications Obesity - physiopathology Renal Insufficiency - blood Renal Insufficiency - drug therapy Renal Insufficiency - prevention & control renin-angiotensin-aldosterone system Spironolactone - administration & dosage Spironolactone - analogs & derivatives Tetrazoles - administration & dosage Treatment Outcome Vasodilator Agents - administration & dosage |
| title | Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure |
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