suPAR: A New Biomarker for Cardiovascular Disease?
Abstract The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular e...
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| Veröffentlicht in: | Canadian journal of cardiology 2015-10, Vol.31 (10), p.1293-1302 |
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| container_title | Canadian journal of cardiology |
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| creator | Hodges, Gethin W., MBBS Bang, Casper N., MD, PhD Wachtell, Kristian, MD, PhD, DMSci, FAHA Eugen-Olsen, Jesper, PhD Jeppesen, Jørgen L., MD, DMSci |
| description | Abstract The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events. |
| doi_str_mv | 10.1016/j.cjca.2015.03.023 |
| format | Article |
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Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.</description><identifier>ISSN: 0828-282X</identifier><identifier>EISSN: 1916-7075</identifier><identifier>DOI: 10.1016/j.cjca.2015.03.023</identifier><identifier>PMID: 26118447</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Biomarkers - blood ; Cardiovascular ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; Humans ; Inflammation - blood ; Predictive Value of Tests ; Prognosis ; Receptors, Urokinase Plasminogen Activator - blood</subject><ispartof>Canadian journal of cardiology, 2015-10, Vol.31 (10), p.1293-1302</ispartof><rights>Canadian Cardiovascular Society</rights><rights>2015 Canadian Cardiovascular Society</rights><rights>Copyright © 2015 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-66eb9e9402657603684b8d070f5d859aef1d44dcd7e2b0025298c4798f234a043</citedby><cites>FETCH-LOGICAL-c547t-66eb9e9402657603684b8d070f5d859aef1d44dcd7e2b0025298c4798f234a043</cites><orcidid>0000-0002-4630-4275</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cjca.2015.03.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26118447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hodges, Gethin W., MBBS</creatorcontrib><creatorcontrib>Bang, Casper N., MD, PhD</creatorcontrib><creatorcontrib>Wachtell, Kristian, MD, PhD, DMSci, FAHA</creatorcontrib><creatorcontrib>Eugen-Olsen, Jesper, PhD</creatorcontrib><creatorcontrib>Jeppesen, Jørgen L., MD, DMSci</creatorcontrib><title>suPAR: A New Biomarker for Cardiovascular Disease?</title><title>Canadian journal of cardiology</title><addtitle>Can J Cardiol</addtitle><description>Abstract The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.</description><subject>Biomarkers - blood</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Receptors, Urokinase Plasminogen Activator - blood</subject><issn>0828-282X</issn><issn>1916-7075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAURS1UBAPlD3SBsuwm4dlxbAch0DBQioRoxYfUneWxXySHzGSwJ1T8exwNZcGiq7e590j3PEK-USgoUHHUFra1pmBAqwLKAli5RSa0piKXIKsvZAKKqZwp9meX7MXYAnAqpdghu0xQqjiXE8Li8Ht6d5xNs1v8m537fmHCE4as6UM2M8H5_sVEO3QmZBc-ool49pVsN6aLePB-98njj8uH2c_85tfV9Wx6k9uKy3UuBM5rrDkwUUkBpVB8rhxIaCqnqtpgQx3nzjqJbA7AKlYry2WtGlZyA7zcJ9833FXonweMa73w0WLXmSX2Q9RUUlWnibxMUbaJ2tDHGLDRq-DTkldNQY-udKtHV3p0paHUyVUqHb7zh_kC3Ufln5wUONkEMK188Rh0tB6XFp0PaNfa9f7__NNPddv5pbeme8JXjG0_hGXyp6mOTIO-H781PotWyQZNgDfulYwi</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Hodges, Gethin W., MBBS</creator><creator>Bang, Casper N., MD, PhD</creator><creator>Wachtell, Kristian, MD, PhD, DMSci, FAHA</creator><creator>Eugen-Olsen, Jesper, PhD</creator><creator>Jeppesen, Jørgen L., MD, DMSci</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4630-4275</orcidid></search><sort><creationdate>20151001</creationdate><title>suPAR: A New Biomarker for Cardiovascular Disease?</title><author>Hodges, Gethin W., MBBS ; Bang, Casper N., MD, PhD ; Wachtell, Kristian, MD, PhD, DMSci, FAHA ; Eugen-Olsen, Jesper, PhD ; Jeppesen, Jørgen L., MD, DMSci</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-66eb9e9402657603684b8d070f5d859aef1d44dcd7e2b0025298c4798f234a043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers - blood</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Receptors, Urokinase Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hodges, Gethin W., MBBS</creatorcontrib><creatorcontrib>Bang, Casper N., MD, PhD</creatorcontrib><creatorcontrib>Wachtell, Kristian, MD, PhD, DMSci, FAHA</creatorcontrib><creatorcontrib>Eugen-Olsen, Jesper, PhD</creatorcontrib><creatorcontrib>Jeppesen, Jørgen L., MD, DMSci</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hodges, Gethin W., MBBS</au><au>Bang, Casper N., MD, PhD</au><au>Wachtell, Kristian, MD, PhD, DMSci, FAHA</au><au>Eugen-Olsen, Jesper, PhD</au><au>Jeppesen, Jørgen L., MD, DMSci</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>suPAR: A New Biomarker for Cardiovascular Disease?</atitle><jtitle>Canadian journal of cardiology</jtitle><addtitle>Can J Cardiol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>31</volume><issue>10</issue><spage>1293</spage><epage>1302</epage><pages>1293-1302</pages><issn>0828-282X</issn><eissn>1916-7075</eissn><abstract>Abstract The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>26118447</pmid><doi>10.1016/j.cjca.2015.03.023</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4630-4275</orcidid></addata></record> |
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| ispartof | Canadian journal of cardiology, 2015-10, Vol.31 (10), p.1293-1302 |
| issn | 0828-282X 1916-7075 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biomarkers - blood Cardiovascular Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - physiopathology Humans Inflammation - blood Predictive Value of Tests Prognosis Receptors, Urokinase Plasminogen Activator - blood |
| title | suPAR: A New Biomarker for Cardiovascular Disease? |
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