One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines
A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5- a ]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4 H -1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of p -toluenesulfonic acid...
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| Veröffentlicht in: | Molecular diversity 2015-11, Vol.19 (4), p.709-715 |
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| container_issue | 4 |
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| container_title | Molecular diversity |
| container_volume | 19 |
| creator | Shaabani, Ahmad Seyyedhamzeh, Mozhdeh Ganji, Nasim Hamidzad Sangachin, Mona Armaghan, Mahsa |
| description | A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5-
a
]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4
H
-1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of
p
-toluenesulfonic acid in water within 4–6 h. |
| doi_str_mv | 10.1007/s11030-015-9604-4 |
| format | Article |
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| fulltext | fulltext |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aldehydes - chemistry Amines - chemistry Benzodiazepines - chemical synthesis Benzodiazepines - chemistry Biochemistry Biological diversity Biomedical and Life Sciences Catalysis Chemistry Full-Length Paper Life Sciences Molecular biology Molecular Structure Organic Chemistry Pharmacy Polymer Sciences Triazoles - chemical synthesis Triazoles - chemistry Water |
| title | One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines |
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