Dioxin-Produced Alteration in the Profiles of Fecal and Urinary Metabolomes: A Change in Bile Acids and Its Relevance to Toxicity

This study investigated dioxin-induced changes in metabolomes in pubertal rat excrement. The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or restricting dietary intake (pair-fed group) markedly altered the metabolomic profile including lipids, hormones, and vitamins in the urine and...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2015/10/01, Vol.38(10), pp.1484-1495
Hauptverfasser:	Kakizuka, Saki, Takeda, Tomoki, Komiya, Yukiko, Koba, Akihiko, Uchi, Hiroshi, Yamamoto, Midori, Furue, Masutaka, Ishii, Yuji, Yamada, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-tetrachlorodibenzo-p-dioxin Animals aryl hydrocarbon receptor bile acid Bile Acids and Salts - metabolism Body Weight - drug effects Caloric Restriction Cytochrome P-450 CYP1A1 Eating - drug effects Feces - chemistry Liver - drug effects Liver - growth & development Liver - metabolism Male metabolome Metabolome - drug effects Organ Size Polychlorinated Dibenzodioxins - pharmacology Rats, Wistar Urine - chemistry
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