Toward refinement of the colony-forming unit-granulocyte/macrophage clonogenic assay: Inclusion of a metabolic system

This work represents a first attempt to refine the colony-forming unit-granulocyte/macrophage (CFU-GM) clonogenic assay by incorporating liver microsomes and co-factors as a metabolic system into the in vitro test system in response to an ECVAM recommendation [Gribaldo, L., Bueren, J., Deldar, A., H...

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Veröffentlicht in:	Toxicology (Amsterdam) 2006-08, Vol.20 (5), p.743-749
Hauptverfasser:	Dal Negro, Gianni, Vandin, Luca, Bonato, Monica, Sciuscio, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cefazolin - toxicity Cefotaxime - toxicity Ciprofloxacin - toxicity Colony-forming unit-granulocyte/macrophages Colony-Forming Units Assay - methods Cytochrome P450 Doxorubicin - toxicity Drug metabolism Granulocytes - drug effects Granulocytes - physiology Hematopoietic Stem Cells - drug effects Macrophages - drug effects Macrophages - physiology Male Mice Mice, Inbred C57BL Mice, Inbred DBA Microsomes, Liver - metabolism Rats Rats, Sprague-Dawley Valproic Acid - toxicity Zidovudine - toxicity
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