Choroidal Thickness in Open-angle Glaucoma
PURPOSE:To examine choroidal thickness in open-angle glaucoma. METHODS:The hospital-based case series study included a study group with patients with open-angle glaucoma and a control group. Choroidal thickness was measured by enhanced depth imaging by spectral domain optical coherence tomography. R...
Gespeichert in:
| Veröffentlicht in: | Journal of glaucoma 2015-10, Vol.24 (8), p.619-623 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 623 |
|---|---|
| container_issue | 8 |
| container_start_page | 619 |
| container_title | Journal of glaucoma |
| container_volume | 24 |
| creator | Jonas, Jost B Steinmetz, Philippe Forster, Tessa M Schlichtenbrede, Frank C Harder, Björn C |
| description | PURPOSE:To examine choroidal thickness in open-angle glaucoma.
METHODS:The hospital-based case series study included a study group with patients with open-angle glaucoma and a control group. Choroidal thickness was measured by enhanced depth imaging by spectral domain optical coherence tomography.
RESULTS:The study group included 39 patients (71 eyes) and the control group consisted of 189 patients (228 eyes) with no significant difference between both groups in age (P=0.16) and refractive error (P=0.07). Choroidal thickness in the foveal region (P=0.18), at a distance of 1000 μm from the fovea (P=0.39), 2000 μm from the fovea (P=0.46), and 2500 μm from the fovea (P=0.53) did not vary significantly between both groups. In multivariable analysis with adjustment for age and refractive error, choroidal thickness at the fovea [P=0.12; regression coefficient Bminus−8.60; 95% confidence interval (CI)−19.3, 2.1], at a horizontal distance of 1000 μm from the fovea (P=0.30; regression coefficient B−4.98; 95% CI−14.3, 4.4), 2000 μm from the fovea (P=0.20; regression coefficient B−20.9; 95% CI−53.2, 11.3), and 2500 μm from the fovea (P=0.45; regression coefficient B−2.70; 95% CI−9.67, 4.27) was not significantly associated with the diagnosis of glaucoma. In binary regression analysis with adjustment for age and refractive error, presence of glaucoma was significantly associated neither with subfoveal choroidal thickness [P=0.12; odds ratio (OR)0.997; 95% CI0.993, 1.001] nor with choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.47; OR0.998; 95% CI0.993, 1.002), 2000 μm from the fovea (P=0.23; OR0.997; 95% CI0.993, 1.002), or 2500 μm from the fovea (P=0.46; OR0.998; 95% CI0.992, 1.004).
CONCLUSIONS:After adjusting for age and refractive error, open-angle glaucoma was not significantly associated with a marked thinning or a thickening of the choroid in the foveal and parafoveal region. |
| doi_str_mv | 10.1097/IJG.0000000000000063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1718332835</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718332835</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4263-5bcb217352db74f9fff019991af8872ab2073b5c07122f0d808bb4f9ed7afaac3</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobk7_gUgvRejMR9OklzJ0Tga7meBdSNLE1qXNTFqG_97KpqAXnptzLp73PfAAcIngFMGC3S6e5lP4a3JyBMaIkjzNOHo5Hm5IWQo5LkbgLMY3CDHEGJ2CEaYZonlGxuBmVvng61K6ZF3VetOaGJO6TVZb06ayfXUmmTvZa9_Ic3BipYvm4rAn4Pnhfj17TJer-WJ2t0x1hnOSUqUVRoxQXCqW2cJaC1FRFEhazhmWCkNGFNWQIYwtLDnkSg2cKZm0UmoyAdf73m3w772JnWjqqI1zsjW-jwIxxAnBnNABzfaoDj7GYKzYhrqR4UMgKL4sicGS-GtpiF0dPvSqMeVP6FvLAPA9sPOuMyFuXL8zQVRGuq76v_sT37Nxug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1718332835</pqid></control><display><type>article</type><title>Choroidal Thickness in Open-angle Glaucoma</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Jonas, Jost B ; Steinmetz, Philippe ; Forster, Tessa M ; Schlichtenbrede, Frank C ; Harder, Björn C</creator><creatorcontrib>Jonas, Jost B ; Steinmetz, Philippe ; Forster, Tessa M ; Schlichtenbrede, Frank C ; Harder, Björn C</creatorcontrib><description>PURPOSE:To examine choroidal thickness in open-angle glaucoma.
METHODS:The hospital-based case series study included a study group with patients with open-angle glaucoma and a control group. Choroidal thickness was measured by enhanced depth imaging by spectral domain optical coherence tomography.
RESULTS:The study group included 39 patients (71 eyes) and the control group consisted of 189 patients (228 eyes) with no significant difference between both groups in age (P=0.16) and refractive error (P=0.07). Choroidal thickness in the foveal region (P=0.18), at a distance of 1000 μm from the fovea (P=0.39), 2000 μm from the fovea (P=0.46), and 2500 μm from the fovea (P=0.53) did not vary significantly between both groups. In multivariable analysis with adjustment for age and refractive error, choroidal thickness at the fovea [P=0.12; regression coefficient Bminus−8.60; 95% confidence interval (CI)−19.3, 2.1], at a horizontal distance of 1000 μm from the fovea (P=0.30; regression coefficient B−4.98; 95% CI−14.3, 4.4), 2000 μm from the fovea (P=0.20; regression coefficient B−20.9; 95% CI−53.2, 11.3), and 2500 μm from the fovea (P=0.45; regression coefficient B−2.70; 95% CI−9.67, 4.27) was not significantly associated with the diagnosis of glaucoma. In binary regression analysis with adjustment for age and refractive error, presence of glaucoma was significantly associated neither with subfoveal choroidal thickness [P=0.12; odds ratio (OR)0.997; 95% CI0.993, 1.001] nor with choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.47; OR0.998; 95% CI0.993, 1.002), 2000 μm from the fovea (P=0.23; OR0.997; 95% CI0.993, 1.002), or 2500 μm from the fovea (P=0.46; OR0.998; 95% CI0.992, 1.004).
CONCLUSIONS:After adjusting for age and refractive error, open-angle glaucoma was not significantly associated with a marked thinning or a thickening of the choroid in the foveal and parafoveal region.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0000000000000063</identifier><identifier>PMID: 25415643</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Choroid - pathology ; Female ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure - physiology ; Male ; Middle Aged ; Refractive Errors - pathology ; Regression Analysis ; Tomography, Optical Coherence</subject><ispartof>Journal of glaucoma, 2015-10, Vol.24 (8), p.619-623</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-5bcb217352db74f9fff019991af8872ab2073b5c07122f0d808bb4f9ed7afaac3</citedby><cites>FETCH-LOGICAL-c4263-5bcb217352db74f9fff019991af8872ab2073b5c07122f0d808bb4f9ed7afaac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25415643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonas, Jost B</creatorcontrib><creatorcontrib>Steinmetz, Philippe</creatorcontrib><creatorcontrib>Forster, Tessa M</creatorcontrib><creatorcontrib>Schlichtenbrede, Frank C</creatorcontrib><creatorcontrib>Harder, Björn C</creatorcontrib><title>Choroidal Thickness in Open-angle Glaucoma</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE:To examine choroidal thickness in open-angle glaucoma.
METHODS:The hospital-based case series study included a study group with patients with open-angle glaucoma and a control group. Choroidal thickness was measured by enhanced depth imaging by spectral domain optical coherence tomography.
RESULTS:The study group included 39 patients (71 eyes) and the control group consisted of 189 patients (228 eyes) with no significant difference between both groups in age (P=0.16) and refractive error (P=0.07). Choroidal thickness in the foveal region (P=0.18), at a distance of 1000 μm from the fovea (P=0.39), 2000 μm from the fovea (P=0.46), and 2500 μm from the fovea (P=0.53) did not vary significantly between both groups. In multivariable analysis with adjustment for age and refractive error, choroidal thickness at the fovea [P=0.12; regression coefficient Bminus−8.60; 95% confidence interval (CI)−19.3, 2.1], at a horizontal distance of 1000 μm from the fovea (P=0.30; regression coefficient B−4.98; 95% CI−14.3, 4.4), 2000 μm from the fovea (P=0.20; regression coefficient B−20.9; 95% CI−53.2, 11.3), and 2500 μm from the fovea (P=0.45; regression coefficient B−2.70; 95% CI−9.67, 4.27) was not significantly associated with the diagnosis of glaucoma. In binary regression analysis with adjustment for age and refractive error, presence of glaucoma was significantly associated neither with subfoveal choroidal thickness [P=0.12; odds ratio (OR)0.997; 95% CI0.993, 1.001] nor with choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.47; OR0.998; 95% CI0.993, 1.002), 2000 μm from the fovea (P=0.23; OR0.997; 95% CI0.993, 1.002), or 2500 μm from the fovea (P=0.46; OR0.998; 95% CI0.992, 1.004).
CONCLUSIONS:After adjusting for age and refractive error, open-angle glaucoma was not significantly associated with a marked thinning or a thickening of the choroid in the foveal and parafoveal region.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Choroid - pathology</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Refractive Errors - pathology</subject><subject>Regression Analysis</subject><subject>Tomography, Optical Coherence</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gUgvRejMR9OklzJ0Tga7meBdSNLE1qXNTFqG_97KpqAXnptzLp73PfAAcIngFMGC3S6e5lP4a3JyBMaIkjzNOHo5Hm5IWQo5LkbgLMY3CDHEGJ2CEaYZonlGxuBmVvng61K6ZF3VetOaGJO6TVZb06ayfXUmmTvZa9_Ic3BipYvm4rAn4Pnhfj17TJer-WJ2t0x1hnOSUqUVRoxQXCqW2cJaC1FRFEhazhmWCkNGFNWQIYwtLDnkSg2cKZm0UmoyAdf73m3w772JnWjqqI1zsjW-jwIxxAnBnNABzfaoDj7GYKzYhrqR4UMgKL4sicGS-GtpiF0dPvSqMeVP6FvLAPA9sPOuMyFuXL8zQVRGuq76v_sT37Nxug</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Jonas, Jost B</creator><creator>Steinmetz, Philippe</creator><creator>Forster, Tessa M</creator><creator>Schlichtenbrede, Frank C</creator><creator>Harder, Björn C</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Choroidal Thickness in Open-angle Glaucoma</title><author>Jonas, Jost B ; Steinmetz, Philippe ; Forster, Tessa M ; Schlichtenbrede, Frank C ; Harder, Björn C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-5bcb217352db74f9fff019991af8872ab2073b5c07122f0d808bb4f9ed7afaac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Choroid - pathology</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Refractive Errors - pathology</topic><topic>Regression Analysis</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonas, Jost B</creatorcontrib><creatorcontrib>Steinmetz, Philippe</creatorcontrib><creatorcontrib>Forster, Tessa M</creatorcontrib><creatorcontrib>Schlichtenbrede, Frank C</creatorcontrib><creatorcontrib>Harder, Björn C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonas, Jost B</au><au>Steinmetz, Philippe</au><au>Forster, Tessa M</au><au>Schlichtenbrede, Frank C</au><au>Harder, Björn C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choroidal Thickness in Open-angle Glaucoma</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2015-10</date><risdate>2015</risdate><volume>24</volume><issue>8</issue><spage>619</spage><epage>623</epage><pages>619-623</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSE:To examine choroidal thickness in open-angle glaucoma.
METHODS:The hospital-based case series study included a study group with patients with open-angle glaucoma and a control group. Choroidal thickness was measured by enhanced depth imaging by spectral domain optical coherence tomography.
RESULTS:The study group included 39 patients (71 eyes) and the control group consisted of 189 patients (228 eyes) with no significant difference between both groups in age (P=0.16) and refractive error (P=0.07). Choroidal thickness in the foveal region (P=0.18), at a distance of 1000 μm from the fovea (P=0.39), 2000 μm from the fovea (P=0.46), and 2500 μm from the fovea (P=0.53) did not vary significantly between both groups. In multivariable analysis with adjustment for age and refractive error, choroidal thickness at the fovea [P=0.12; regression coefficient Bminus−8.60; 95% confidence interval (CI)−19.3, 2.1], at a horizontal distance of 1000 μm from the fovea (P=0.30; regression coefficient B−4.98; 95% CI−14.3, 4.4), 2000 μm from the fovea (P=0.20; regression coefficient B−20.9; 95% CI−53.2, 11.3), and 2500 μm from the fovea (P=0.45; regression coefficient B−2.70; 95% CI−9.67, 4.27) was not significantly associated with the diagnosis of glaucoma. In binary regression analysis with adjustment for age and refractive error, presence of glaucoma was significantly associated neither with subfoveal choroidal thickness [P=0.12; odds ratio (OR)0.997; 95% CI0.993, 1.001] nor with choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.47; OR0.998; 95% CI0.993, 1.002), 2000 μm from the fovea (P=0.23; OR0.997; 95% CI0.993, 1.002), or 2500 μm from the fovea (P=0.46; OR0.998; 95% CI0.992, 1.004).
CONCLUSIONS:After adjusting for age and refractive error, open-angle glaucoma was not significantly associated with a marked thinning or a thickening of the choroid in the foveal and parafoveal region.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25415643</pmid><doi>10.1097/IJG.0000000000000063</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1057-0829 |
| ispartof | Journal of glaucoma, 2015-10, Vol.24 (8), p.619-623 |
| issn | 1057-0829 1536-481X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1718332835 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Case-Control Studies Choroid - pathology Female Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure - physiology Male Middle Aged Refractive Errors - pathology Regression Analysis Tomography, Optical Coherence |
| title | Choroidal Thickness in Open-angle Glaucoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A00%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Choroidal%20Thickness%20in%20Open-angle%20Glaucoma&rft.jtitle=Journal%20of%20glaucoma&rft.au=Jonas,%20Jost%20B&rft.date=2015-10&rft.volume=24&rft.issue=8&rft.spage=619&rft.epage=623&rft.pages=619-623&rft.issn=1057-0829&rft.eissn=1536-481X&rft_id=info:doi/10.1097/IJG.0000000000000063&rft_dat=%3Cproquest_cross%3E1718332835%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1718332835&rft_id=info:pmid/25415643&rfr_iscdi=true |