A Mixed-Crystal Lanthanide Zeolite-like Metal–Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker
Two lanthanide zeolite-like metal–organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-...
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-09, Vol.137 (38), p.12203-12206 |
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| container_issue | 38 |
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| container_title | Journal of the American Chemical Society |
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| creator | Zhang, Shi-Yuan Shi, Wei Cheng, Peng Zaworotko, Michael J |
| description | Two lanthanide zeolite-like metal–organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4–43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA. |
| doi_str_mv | 10.1021/jacs.5b06929 |
| format | Article |
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Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4–43.3 μM). 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Am. Chem. Soc</addtitle><description>Two lanthanide zeolite-like metal–organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4–43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.</description><subject>Biomarkers, Tumor - analysis</subject><subject>Female</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Genital Neoplasms, Female - diagnosis</subject><subject>Humans</subject><subject>Lanthanoid Series Elements - chemistry</subject><subject>Lysophospholipids - analysis</subject><subject>Molecular Structure</subject><subject>Organometallic Compounds - chemistry</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Zeolites - chemistry</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>EIF</sourceid><recordid>eNptkL1PGzEYxq2qqElpN2bksQMH_roPj-FEWqSgLLCwnN743iNOLudg3wmyde7a_7B_SR0RYGGwLev5vY8fP4SccHbOmeAXKzDhPF2wTAv9iYx5KliScpF9JmPGmEjyIpMj8jWEVbwqUfAvZCQymaZayzH5M6E39hnrpPS70ENLZ9D1S-hsjfQeXWt7TFq7RnqDUf33--_cP0TV0KmHDT45v6YQKNBpOziPwWDX0-uutgZ652kT12wX3HbpwnYJvY0CnRhbn8WREjqDnl5atwG_Rv-NHDXQBvx-OI_J3fTqtvyVzOY_r8vJLIGYvk9yBYvcpBLkwmDW8Ewjz-MGkjOFQqdGN0qDqEWumhwEqggrLlFKVUhAeUx-vPhuvXscMPTVxsbgbQsduiFUPOeFlEwVOqJnL6jxLgSPTbX1NqbdVZxV-_arffvVof2Inx6ch8UG6zf4te73p_dTKzf4Ln70Y6__aGqPuw</recordid><startdate>20150930</startdate><enddate>20150930</enddate><creator>Zhang, Shi-Yuan</creator><creator>Shi, Wei</creator><creator>Cheng, Peng</creator><creator>Zaworotko, Michael J</creator><general>American Chemical Society</general><scope>N~.</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150930</creationdate><title>A Mixed-Crystal Lanthanide Zeolite-like Metal–Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker</title><author>Zhang, Shi-Yuan ; Shi, Wei ; Cheng, Peng ; Zaworotko, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a428t-74ab7c53a3bce6f169e1769ea3104e295c9f49a2d274f7a2e4c53413e33483ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers, Tumor - analysis</topic><topic>Female</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Genital Neoplasms, Female - diagnosis</topic><topic>Humans</topic><topic>Lanthanoid Series Elements - chemistry</topic><topic>Lysophospholipids - analysis</topic><topic>Molecular Structure</topic><topic>Organometallic Compounds - chemistry</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Zeolites - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shi-Yuan</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Cheng, Peng</creatorcontrib><creatorcontrib>Zaworotko, Michael J</creatorcontrib><collection>American Chemical Society (ACS) Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shi-Yuan</au><au>Shi, Wei</au><au>Cheng, Peng</au><au>Zaworotko, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Mixed-Crystal Lanthanide Zeolite-like Metal–Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2015-09-30</date><risdate>2015</risdate><volume>137</volume><issue>38</issue><spage>12203</spage><epage>12206</epage><pages>12203-12206</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>Two lanthanide zeolite-like metal–organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb3+ and Eu3+ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4–43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26355993</pmid><doi>10.1021/jacs.5b06929</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2015-09, Vol.137 (38), p.12203-12206 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Biomarkers, Tumor - analysis Female Fluorescent Dyes - chemistry Genital Neoplasms, Female - diagnosis Humans Lanthanoid Series Elements - chemistry Lysophospholipids - analysis Molecular Structure Organometallic Compounds - chemistry Ovarian Neoplasms - diagnosis Zeolites - chemistry |
| title | A Mixed-Crystal Lanthanide Zeolite-like Metal–Organic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker |
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