Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease

The incorporation of [alpha-32P]-uridine triphosphate into DNA transcription products was examined in short post-mortem interval (PMI) human brain neocortical nuclei (n, 22; PMI, 0.5-24 h) using run-on-gene transcription. Reverse Northern dot-blot hybridization of newly synthesized RNA against eithe...

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Veröffentlicht in:	Journal of molecular neuroscience 1998-08, Vol.11 (1), p.67-78
Hauptverfasser:	Lukiw, W J, LeBlanc, H J, Carver, L A, McLachlan, D R, Bazan, N G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alu Elements - genetics Aluminum Aluminum - metabolism Aluminum - toxicity Cell Nucleus - drug effects Cell Nucleus - genetics Cell Nucleus - metabolism Deoxyribonucleic acid DNA DNA, Complementary - genetics Dose-Response Relationship, Drug Female Genetics Glial Fibrillary Acidic Protein - genetics Humans Male Middle Aged Neocortex - cytology Neocortex - drug effects Neocortex - metabolism Neurodegenerative Diseases - chemically induced Neurofilament Proteins - genetics RNA polymerase RNA Polymerase I - metabolism RNA Polymerase II - metabolism RNA, Messenger - biosynthesis RNA, Ribosomal - genetics Transcription, Genetic - drug effects
Online-Zugang:	Volltext
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