In-vivo pharmacology of Trace-Amine Associated Receptor 1
Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. These compounds exert their effect by activating a class of G protein-coupled receptors termed Trace-Amine Associated Receptors (TAARs), where TAAR1 is...
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| Veröffentlicht in: | European journal of pharmacology 2015-09, Vol.763 (Pt B), p.136-142 |
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| container_issue | Pt B |
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| container_title | European journal of pharmacology |
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| creator | Lam, Vincent M. Espinoza, Stefano Gerasimov, Andrey S. Gainetdinov, Raul R. Salahpour, Ali |
| description | Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. These compounds exert their effect by activating a class of G protein-coupled receptors termed Trace-Amine Associated Receptors (TAARs), where TAAR1 is the only human receptor that has been shown to bind endogenous TAs. Most of the studies have focused on studying the role of TAAR1 on modulation of the dopamine transmission. These studies indicate that TAAR1 is a negative regulator of dopamine transmission making TAAR1 a novel target for neuropsychiatric disorders that arises from dopamine dysfunction such as schizophrenia. This review discusses the unique pharmacology of TAAR1 with the major focus on the physiological role of TAAR1 and its modulation of dopamine transmission. |
| doi_str_mv | 10.1016/j.ejphar.2015.06.026 |
| format | Article |
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This review discusses the unique pharmacology of TAAR1 with the major focus on the physiological role of TAAR1 and its modulation of dopamine transmission.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2015.06.026</identifier><identifier>PMID: 26093041</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amines - metabolism ; Animals ; Dopamine ; Dopamine - metabolism ; Humans ; Ligands ; Neurological disorders ; Pharmacological Phenomena ; Receptors, G-Protein-Coupled - metabolism ; Signal Transduction - drug effects ; TAAR1 ; Trace-amines</subject><ispartof>European journal of pharmacology, 2015-09, Vol.763 (Pt B), p.136-142</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. 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This review discusses the unique pharmacology of TAAR1 with the major focus on the physiological role of TAAR1 and its modulation of dopamine transmission.</description><subject>Amines - metabolism</subject><subject>Animals</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Humans</subject><subject>Ligands</subject><subject>Neurological disorders</subject><subject>Pharmacological Phenomena</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>TAAR1</subject><subject>Trace-amines</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gUgvvWk9SdO0uRHG8GMwEGRehzQ51Yy1mUk32L-3Y9NLr87Fed7z8RBySyGjQMXDKsPV5kuHjAEtMhAZMHFGxrQqZQolZedkDEB5yqSUI3IV4woACsmKSzJiAmQOnI6JnHfpzu18chjVauPX_nOf-CZZBm0wnbauw2QaozdO92iTdzS46X1I6DW5aPQ64s2pTsjH89Ny9pou3l7ms-kiNTxnfVoj5kVT1qXWzFrBaIEcapA6FzBcgFAM_cpwMJTnVha1GKgGQFtpDa-rfELuj3M3wX9vMfaqddHgeq079NuoaEkrKEuRH1B-RE3wMQZs1Ca4Voe9oqAO0tRKHaWpgzQFQg3ShtjdacO2btH-hX4tDcDjEcDhz53DoKJx2Bm0LqDplfXu_w0_u09-FQ</recordid><startdate>20150915</startdate><enddate>20150915</enddate><creator>Lam, Vincent M.</creator><creator>Espinoza, Stefano</creator><creator>Gerasimov, Andrey S.</creator><creator>Gainetdinov, Raul R.</creator><creator>Salahpour, Ali</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150915</creationdate><title>In-vivo pharmacology of Trace-Amine Associated Receptor 1</title><author>Lam, Vincent M. ; Espinoza, Stefano ; Gerasimov, Andrey S. ; Gainetdinov, Raul R. ; Salahpour, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-bee35f7b7aa2dd6215e40b09a360041e05e358c40c143d95b6dd6f00ad9dc4b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amines - metabolism</topic><topic>Animals</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Humans</topic><topic>Ligands</topic><topic>Neurological disorders</topic><topic>Pharmacological Phenomena</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>TAAR1</topic><topic>Trace-amines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Vincent M.</creatorcontrib><creatorcontrib>Espinoza, Stefano</creatorcontrib><creatorcontrib>Gerasimov, Andrey S.</creatorcontrib><creatorcontrib>Gainetdinov, Raul R.</creatorcontrib><creatorcontrib>Salahpour, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Vincent M.</au><au>Espinoza, Stefano</au><au>Gerasimov, Andrey S.</au><au>Gainetdinov, Raul R.</au><au>Salahpour, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vivo pharmacology of Trace-Amine Associated Receptor 1</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2015-09-15</date><risdate>2015</risdate><volume>763</volume><issue>Pt B</issue><spage>136</spage><epage>142</epage><pages>136-142</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. 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| ispartof | European journal of pharmacology, 2015-09, Vol.763 (Pt B), p.136-142 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amines - metabolism Animals Dopamine Dopamine - metabolism Humans Ligands Neurological disorders Pharmacological Phenomena Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects TAAR1 Trace-amines |
| title | In-vivo pharmacology of Trace-Amine Associated Receptor 1 |
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