Specificity of interleukin–1β-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist
The purpose of this study was to examine specificity in the effects of interleukin-1β (IL-1β) on monoamines in various areas of the hypothalamus. Adult male rats were injected i.p. with saline or 2.5 or 5.0 μg of IL-1β or were pretreated with 500 μg of IL-1 receptor antagonist (IL-1ra) followed 5 mi...
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| Veröffentlicht in: | Brain research bulletin 1998-09, Vol.47 (1), p.29-34 |
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| creator | MohanKumar, Sheba M.J. MohanKumar, P.S. Quadri, S.K. |
| description | The purpose of this study was to examine specificity in the effects of interleukin-1β (IL-1β) on monoamines in various areas of the hypothalamus. Adult male rats were injected i.p. with saline or 2.5 or 5.0 μg of IL-1β or were pretreated with 500 μg of IL-1 receptor antagonist (IL-1ra) followed 5 min later by 5 μg of IL-1β. The paraventricular nucleus (PVN), arcuate nucleus (AN), median eminence (ME), and medial preoptic area (MPA) were microdissected and analyzed for neurotransmitter concentrations by high-performance liquid chromatography with electrochemical detection (HPLC-EC). In the PVN, IL treatment produced significant increases in the concentrations of norepinephrine (NE), dopamine (DA), DA metabolite dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). IL-1 treatment increased the concentrations of NE and DA in the AN but only of NE in the ME, and it was without any effect in the MPA. Pretreatment with IL-1ra completely blocked the IL-1 effects. It is concluded that IL-1 induces highly specific changes in monoamine metabolism in the hypothalamus, and the nature of these changes depends on specific hypothalamic nuclei. |
| doi_str_mv | 10.1016/S0361-9230(98)00037-9 |
| format | Article |
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Adult male rats were injected i.p. with saline or 2.5 or 5.0 μg of IL-1β or were pretreated with 500 μg of IL-1 receptor antagonist (IL-1ra) followed 5 min later by 5 μg of IL-1β. The paraventricular nucleus (PVN), arcuate nucleus (AN), median eminence (ME), and medial preoptic area (MPA) were microdissected and analyzed for neurotransmitter concentrations by high-performance liquid chromatography with electrochemical detection (HPLC-EC). In the PVN, IL treatment produced significant increases in the concentrations of norepinephrine (NE), dopamine (DA), DA metabolite dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). IL-1 treatment increased the concentrations of NE and DA in the AN but only of NE in the ME, and it was without any effect in the MPA. Pretreatment with IL-1ra completely blocked the IL-1 effects. It is concluded that IL-1 induces highly specific changes in monoamine metabolism in the hypothalamus, and the nature of these changes depends on specific hypothalamic nuclei.</description><subject>Arcuate Nucleus</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus</subject><subject>Interleukin-1 receptor antagonist</subject><subject>Interleukin-1β</subject><subject>Medial preoptic area</subject><subject>Median eminence</subject><subject>Monoamines</subject><subject>Paraventricular nucleus</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkU1uFDEQhS0EEkPgCEheIASLBrs947bZoCjiT4rEIrC2asrVGZMeu7HdSLPjDOQmOQiH4CT0zEQRO1a1qO_VU73H2FMpXkkh9esLobRsbKvEC2teCiFU19h7bCFNp5q2W3b32eIOecgelfJthrRZ6QX7dTEShj5gqDueeh5ipTzQdBXin5_X8vdNE6KfkDzHDcRLKjPBtykm2IZIHFNEijVDDSkedpvdmOoGhnmPPE44UHjD10PCK_DE17t_HRrJMyGNNWUOscJliqHUx-xBD0OhJ7fzhH19_-7L2cfm_POHT2en5w0q3dWmW5NWSqul1mgUKt9Zo9vV_LRXFrRAAN9KMmC8UGgVGiklKNMSSt3alTphz493x5y-T1Sq24aCNAwQKU3FyU4aoQ_g6ghiTqVk6t2Ywxbyzknh9g24QwNuH6-zxh0acHbWPbs1gIIw9BkihnInbpfS2naPvT1iND_7I1B2BQPNufowp1OdT-E_Rn8BE82e4w</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>MohanKumar, Sheba M.J.</creator><creator>MohanKumar, P.S.</creator><creator>Quadri, S.K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19980901</creationdate><title>Specificity of interleukin–1β-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist</title><author>MohanKumar, Sheba M.J. ; MohanKumar, P.S. ; Quadri, S.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-7be63363466c83c3d798625187d39a60caad21e8a8d03c93c8111a382ec162953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Arcuate Nucleus</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus</topic><topic>Interleukin-1 receptor antagonist</topic><topic>Interleukin-1β</topic><topic>Medial preoptic area</topic><topic>Median eminence</topic><topic>Monoamines</topic><topic>Paraventricular nucleus</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MohanKumar, Sheba M.J.</creatorcontrib><creatorcontrib>MohanKumar, P.S.</creatorcontrib><creatorcontrib>Quadri, S.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MohanKumar, Sheba M.J.</au><au>MohanKumar, P.S.</au><au>Quadri, S.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specificity of interleukin–1β-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist</atitle><jtitle>Brain research bulletin</jtitle><date>1998-09-01</date><risdate>1998</risdate><volume>47</volume><issue>1</issue><spage>29</spage><epage>34</epage><pages>29-34</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The purpose of this study was to examine specificity in the effects of interleukin-1β (IL-1β) on monoamines in various areas of the hypothalamus. Adult male rats were injected i.p. with saline or 2.5 or 5.0 μg of IL-1β or were pretreated with 500 μg of IL-1 receptor antagonist (IL-1ra) followed 5 min later by 5 μg of IL-1β. The paraventricular nucleus (PVN), arcuate nucleus (AN), median eminence (ME), and medial preoptic area (MPA) were microdissected and analyzed for neurotransmitter concentrations by high-performance liquid chromatography with electrochemical detection (HPLC-EC). In the PVN, IL treatment produced significant increases in the concentrations of norepinephrine (NE), dopamine (DA), DA metabolite dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). IL-1 treatment increased the concentrations of NE and DA in the AN but only of NE in the ME, and it was without any effect in the MPA. Pretreatment with IL-1ra completely blocked the IL-1 effects. 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| ispartof | Brain research bulletin, 1998-09, Vol.47 (1), p.29-34 |
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| subjects | Arcuate Nucleus Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology Hypothalamus Interleukin-1 receptor antagonist Interleukin-1β Medial preoptic area Median eminence Monoamines Paraventricular nucleus Vertebrates: nervous system and sense organs |
| title | Specificity of interleukin–1β-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist |
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