Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

Telomerase is a protein-RNA enzyme complex that adds a six-base DNA sequence (TTAGGG) to the ends of chromosomes and thereby prevents their shortening. Reduced telomerase activity is associated with cell differentiation and accelerated cellular senescence, whereas increased telomerase activity is as...

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Veröffentlicht in:	The Journal of biological chemistry 1999-03, Vol.274 (11), p.7264-7271
Hauptverfasser:	Fu, Weiming, Begley, James G., Killen, Michael W., Mattson, Mark P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Animals Apoptosis - drug effects Apoptosis - physiology Base Sequence Cell Differentiation DNA Primers Enzyme Inhibitors - pharmacology PC12 Cells Pheochromocytoma - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Telomerase - antagonists & inhibitors Telomerase - physiology
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