CXCL10-induced cell death in neurons: role of calcium dysregulation

Chemokines play a key role in the regulation of central nervous system disease. CXCL10 over‐expression has been observed in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease and HIV‐associated dementia. More recent studies by others and us have shown that CXC...

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Veröffentlicht in:	The European journal of neuroscience 2006-02, Vol.23 (4), p.957-964
Hauptverfasser:	Sui, Yongjun, Stehno-Bittel, Lisa, Li, Shanping, Loganathan, Rajprasad, Dhillon, Navneet K., Pinson, David, Nath, Avindra, Kolson, Dennis, Narayan, Opendra, Buch, Shilpa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Blotting, Western - methods Brain - cytology Calcium - metabolism Caspase 3 caspases Caspases - metabolism Cell Count - methods Cell Death - drug effects Cell Death - physiology Cells, Cultured chemokine Chemokine CXCL10 Chemokines, CXC - pharmacology CXCL10 Cytosol - drug effects Cytosol - metabolism Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Fetus Gene Expression - drug effects HIV-associated dementia human Human immunodeficiency virus Humans Immunohistochemistry - methods Mitochondria - drug effects Mitochondria - metabolism Models, Neurological neuronal apoptosis Neurons - cytology Neurons - drug effects Neurons - metabolism Teratocarcinoma Thapsigargin - pharmacology Xanthenes - metabolism
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