Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats
In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those...
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| Veröffentlicht in: | Cancer letters 2006-04, Vol.235 (2), p.266-271 |
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| container_title | Cancer letters |
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| creator | Cos, Samuel Mediavilla, Dolores Martínez-Campa, Carlos González, Alicia Alonso-González, Carolina Sánchez-Barceló, Emilio J. |
| description | In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors. |
| doi_str_mv | 10.1016/j.canlet.2005.04.025 |
| format | Article |
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Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2005.04.025</identifier><identifier>PMID: 15950374</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>6-Sulfatoxymelatonin ; 9,10-Dimethyl-1,2-benzanthracene ; Adenocarcinoma - chemically induced ; Adenocarcinoma - pathology ; Animals ; Body Weight ; Breast cancer ; Circadian Rhythm ; Darkness ; DMBA ; Estradiol ; Estradiol - blood ; Estrus ; Experiments ; Female ; Hypotheses ; Light ; Light pollution ; Lighting ; Mammary cancer ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - mortality ; Mammary Neoplasms, Experimental - pathology ; Melatonin ; Melatonin - analogs & derivatives ; Melatonin - urine ; Metabolites ; Mortality ; Rats ; Rats, Sprague-Dawley ; Rodents ; Survival Rate ; Tumors</subject><ispartof>Cancer letters, 2006-04, Vol.235 (2), p.266-271</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Apr 28, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-c8de6caf3ade9dea920b64315c445331374addaec028b28f96f86146a84f0003</citedby><cites>FETCH-LOGICAL-c419t-c8de6caf3ade9dea920b64315c445331374addaec028b28f96f86146a84f0003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2005.04.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15950374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cos, Samuel</creatorcontrib><creatorcontrib>Mediavilla, Dolores</creatorcontrib><creatorcontrib>Martínez-Campa, Carlos</creatorcontrib><creatorcontrib>González, Alicia</creatorcontrib><creatorcontrib>Alonso-González, Carolina</creatorcontrib><creatorcontrib>Sánchez-Barceló, Emilio J.</creatorcontrib><title>Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors.</description><subject>6-Sulfatoxymelatonin</subject><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Adenocarcinoma - chemically induced</subject><subject>Adenocarcinoma - pathology</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Breast cancer</subject><subject>Circadian Rhythm</subject><subject>Darkness</subject><subject>DMBA</subject><subject>Estradiol</subject><subject>Estradiol - blood</subject><subject>Estrus</subject><subject>Experiments</subject><subject>Female</subject><subject>Hypotheses</subject><subject>Light</subject><subject>Light pollution</subject><subject>Lighting</subject><subject>Mammary cancer</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - mortality</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Melatonin</subject><subject>Melatonin - analogs & derivatives</subject><subject>Melatonin - urine</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrHCEYhqUkNNu0_6AUodDbTHTUGedSSNOkDSTksndx9ZtdlxndqJM0_74uuxDIISe_w_O-ft-D0FdKakpoe7GtjfYj5LohRNSE16QRH9CCyq6pul6SE7QgjPCKSSbO0KeUtqSAvBMf0RkVvSCs4wukrv_tQpoj4Bzw6NabXOlc-f2AnTcRdIKE8wbwOobnvMFhwL_vf11WztvZgMWTniYdX7C24IPR0TgfJp1KGEed02d0OugxwZfje46WN9fLq7_V3cOf26vLu8pw2ufKSAut0QMrNb0F3Tdk1XJGheFcMEbLrtpaDYY0ctXIoW8H2VLeasmHchY7Rz8OtbsYHmdIWU0uGRhH7SHMSdGOdqJoK-D3N-A2zNGX1RQVRLCONbIrFD9QJoaUIgxqF93-TEWJ2ttXW3Wwr_b2FeGq2C-xb8fyeTWBfQ0ddRfg5wGAouLJQVTJOPDFo4tgsrLBvf_Df3x0l5c</recordid><startdate>20060428</startdate><enddate>20060428</enddate><creator>Cos, Samuel</creator><creator>Mediavilla, Dolores</creator><creator>Martínez-Campa, Carlos</creator><creator>González, Alicia</creator><creator>Alonso-González, Carolina</creator><creator>Sánchez-Barceló, Emilio J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20060428</creationdate><title>Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats</title><author>Cos, Samuel ; Mediavilla, Dolores ; Martínez-Campa, Carlos ; González, Alicia ; Alonso-González, Carolina ; Sánchez-Barceló, Emilio J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c8de6caf3ade9dea920b64315c445331374addaec028b28f96f86146a84f0003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>6-Sulfatoxymelatonin</topic><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>Adenocarcinoma - chemically induced</topic><topic>Adenocarcinoma - pathology</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Breast cancer</topic><topic>Circadian Rhythm</topic><topic>Darkness</topic><topic>DMBA</topic><topic>Estradiol</topic><topic>Estradiol - blood</topic><topic>Estrus</topic><topic>Experiments</topic><topic>Female</topic><topic>Hypotheses</topic><topic>Light</topic><topic>Light pollution</topic><topic>Lighting</topic><topic>Mammary cancer</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - mortality</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Melatonin</topic><topic>Melatonin - analogs & derivatives</topic><topic>Melatonin - urine</topic><topic>Metabolites</topic><topic>Mortality</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cos, Samuel</creatorcontrib><creatorcontrib>Mediavilla, Dolores</creatorcontrib><creatorcontrib>Martínez-Campa, Carlos</creatorcontrib><creatorcontrib>González, Alicia</creatorcontrib><creatorcontrib>Alonso-González, Carolina</creatorcontrib><creatorcontrib>Sánchez-Barceló, Emilio J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cos, Samuel</au><au>Mediavilla, Dolores</au><au>Martínez-Campa, Carlos</au><au>González, Alicia</au><au>Alonso-González, Carolina</au><au>Sánchez-Barceló, Emilio J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2006-04-28</date><risdate>2006</risdate><volume>235</volume><issue>2</issue><spage>266</spage><epage>271</epage><pages>266-271</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15950374</pmid><doi>10.1016/j.canlet.2005.04.025</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer letters, 2006-04, Vol.235 (2), p.266-271 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 6-Sulfatoxymelatonin 9,10-Dimethyl-1,2-benzanthracene Adenocarcinoma - chemically induced Adenocarcinoma - pathology Animals Body Weight Breast cancer Circadian Rhythm Darkness DMBA Estradiol Estradiol - blood Estrus Experiments Female Hypotheses Light Light pollution Lighting Mammary cancer Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - mortality Mammary Neoplasms, Experimental - pathology Melatonin Melatonin - analogs & derivatives Melatonin - urine Metabolites Mortality Rats Rats, Sprague-Dawley Rodents Survival Rate Tumors |
| title | Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats |
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