Colonic bacterial composition in Parkinson's disease

Introduction We showed that Parkinson's disease (PD) patients have alpha‐synuclein (α‐Syn) aggregation in their colon with evidence of colonic inflammation. If PD patients have altered colonic microbiota, dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and P...

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Veröffentlicht in:	Movement disorders 2015-09, Vol.30 (10), p.1351-1360
Hauptverfasser:	Keshavarzian, Ali, Green, Stefan J., Engen, Phillip A., Voigt, Robin M., Naqib, Ankur, Forsyth, Christopher B., Mutlu, Ece, Shannon, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	a-synuclein Adult Aged alpha-Synuclein - chemistry Colon, Sigmoid - microbiology colonic mucosa and feces dysbiosis Dysbiosis - complications Feces - microbiology Female Humans Intestinal Mucosa - microbiology Male Microbiota Middle Aged Movement disorders Parkinson Disease - etiology Protein Folding Proteobacteria putative butyrate producing short-chain fatty acids Ralstonia
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