The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample
Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample. 269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensio...
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| Veröffentlicht in: | International psychogeriatrics 2015-10, Vol.27 (10), p.1687-1692 |
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| creator | Vieira, Renalice Neves Magalhães, Joalce Dornelas Sant’Anna, Jemima Moriguti, Mateus Massao de Miranda, Débora Marques De Marco, Luiz de Moraes, Edgar Nunes Romano-Silva, Marco Aurélio Bicalho, Maria Aparecida Camargos de Paula, Jonas Jardim Cintra, Marco Túlio Gualberto |
| description | Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.
269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.
GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.
Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles. |
| doi_str_mv | 10.1017/S1041610215000514 |
| format | Article |
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269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.
GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.
Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.</description><identifier>ISSN: 1041-6102</identifier><identifier>EISSN: 1741-203X</identifier><identifier>DOI: 10.1017/S1041610215000514</identifier><identifier>PMID: 25853819</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - genetics ; Alzheimer's disease ; APOE ; Apolipoprotein E4 - genetics ; BDNF ; Brain-Derived Neurotrophic Factor - genetics ; Brazil ; Case-Control Studies ; Female ; GAB2 ; Genes ; Genetic Predisposition to Disease ; Humans ; Logistic Models ; Male ; Middle Aged ; Older people ; Polymorphism ; Polymorphism, Genetic ; Risk Factors</subject><ispartof>International psychogeriatrics, 2015-10, Vol.27 (10), p.1687-1692</ispartof><rights>Copyright © International Psychogeriatric Association 2015</rights><rights>2015 International Psychogeriatric Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-d74244274ed11d6ace0c8aa9aecaed040b2c6bf5da43dab868248e3f4ca1fe953</citedby><cites>FETCH-LOGICAL-c458t-d74244274ed11d6ace0c8aa9aecaed040b2c6bf5da43dab868248e3f4ca1fe953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1041610215000514/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12825,27901,27902,30976,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25853819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieira, Renalice Neves</creatorcontrib><creatorcontrib>Magalhães, Joalce Dornelas</creatorcontrib><creatorcontrib>Sant’Anna, Jemima</creatorcontrib><creatorcontrib>Moriguti, Mateus Massao</creatorcontrib><creatorcontrib>de Miranda, Débora Marques</creatorcontrib><creatorcontrib>De Marco, Luiz</creatorcontrib><creatorcontrib>de Moraes, Edgar Nunes</creatorcontrib><creatorcontrib>Romano-Silva, Marco Aurélio</creatorcontrib><creatorcontrib>Bicalho, Maria Aparecida Camargos</creatorcontrib><creatorcontrib>de Paula, Jonas Jardim</creatorcontrib><creatorcontrib>Cintra, Marco Túlio Gualberto</creatorcontrib><title>The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample</title><title>International psychogeriatrics</title><addtitle>Int. Psychogeriatr</addtitle><description>Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.
269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.
GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.
Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>APOE</subject><subject>Apolipoprotein E4 - genetics</subject><subject>BDNF</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>GAB2</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><issn>1041-6102</issn><issn>1741-203X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhi1ERb_4Ab0gSxzKJcXj2PkQp93SL6miB4rELXLsCevixKmdrbT99XW7W4SKQJxszTzvq5l5CTkAdgQMyo9fgQkogHGQjDEJ4hXZgVJAxln-_XX6p3b22N8muzHeMMZlDuIN2eayknkF9Q4ZrhdIz2ZzTtVg6Pzzl1M6erfqfRgXNvbxqTwlJtj4k3Y-UKcmzPwQcaIzd79A22M4jNTYiCoitUOSUHQGg1vReVD31tlUiaofHe6TrU65iG837x75dnpyfXyeXV6dXRzPLjMtZDVlphRcCF4KNACmUBqZrpSqFWqFhgnWcl20nTRK5Ea1VVFxUWHeCa2gw1rme-TD2ncM_naJcWp6GzU6pwb0y9hAme5U54X8H5TVJSsKWSf0_Qv0xi_DkBZ5onjBOeOJgjWlg48xYNeMwfYqrBpgzWNuzR-5Jc27jfOy7dH8UjwHlYBPawDT1e4shiZqi4NGYwPqqTHe_tM-34yk-jZY8wN_m_yvqgdoMbMx</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Vieira, Renalice Neves</creator><creator>Magalhães, Joalce Dornelas</creator><creator>Sant’Anna, Jemima</creator><creator>Moriguti, Mateus Massao</creator><creator>de Miranda, Débora Marques</creator><creator>De Marco, Luiz</creator><creator>de Moraes, Edgar Nunes</creator><creator>Romano-Silva, Marco Aurélio</creator><creator>Bicalho, Maria Aparecida Camargos</creator><creator>de Paula, Jonas Jardim</creator><creator>Cintra, Marco Túlio Gualberto</creator><general>Cambridge University Press</general><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201510</creationdate><title>The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample</title><author>Vieira, Renalice Neves ; Magalhães, Joalce Dornelas ; Sant’Anna, Jemima ; Moriguti, Mateus Massao ; de Miranda, Débora Marques ; De Marco, Luiz ; de Moraes, Edgar Nunes ; Romano-Silva, Marco Aurélio ; Bicalho, Maria Aparecida Camargos ; de Paula, Jonas Jardim ; Cintra, Marco Túlio Gualberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-d74244274ed11d6ace0c8aa9aecaed040b2c6bf5da43dab868248e3f4ca1fe953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>APOE</topic><topic>Apolipoprotein E4 - genetics</topic><topic>BDNF</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brazil</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>GAB2</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vieira, Renalice Neves</creatorcontrib><creatorcontrib>Magalhães, Joalce Dornelas</creatorcontrib><creatorcontrib>Sant’Anna, Jemima</creatorcontrib><creatorcontrib>Moriguti, Mateus Massao</creatorcontrib><creatorcontrib>de Miranda, Débora Marques</creatorcontrib><creatorcontrib>De Marco, Luiz</creatorcontrib><creatorcontrib>de Moraes, Edgar Nunes</creatorcontrib><creatorcontrib>Romano-Silva, Marco Aurélio</creatorcontrib><creatorcontrib>Bicalho, Maria Aparecida Camargos</creatorcontrib><creatorcontrib>de Paula, Jonas Jardim</creatorcontrib><creatorcontrib>Cintra, Marco Túlio Gualberto</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>International psychogeriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vieira, Renalice Neves</au><au>Magalhães, Joalce Dornelas</au><au>Sant’Anna, Jemima</au><au>Moriguti, Mateus Massao</au><au>de Miranda, Débora Marques</au><au>De Marco, Luiz</au><au>de Moraes, Edgar Nunes</au><au>Romano-Silva, Marco Aurélio</au><au>Bicalho, Maria Aparecida Camargos</au><au>de Paula, Jonas Jardim</au><au>Cintra, Marco Túlio Gualberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample</atitle><jtitle>International psychogeriatrics</jtitle><addtitle>Int. Psychogeriatr</addtitle><date>2015-10</date><risdate>2015</risdate><volume>27</volume><issue>10</issue><spage>1687</spage><epage>1692</epage><pages>1687-1692</pages><issn>1041-6102</issn><eissn>1741-203X</eissn><abstract>Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.
269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.
GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.
Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>25853819</pmid><doi>10.1017/S1041610215000514</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International psychogeriatrics, 2015-10, Vol.27 (10), p.1687-1692 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge Journals |
| subjects | Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer's disease APOE Apolipoprotein E4 - genetics BDNF Brain-Derived Neurotrophic Factor - genetics Brazil Case-Control Studies Female GAB2 Genes Genetic Predisposition to Disease Humans Logistic Models Male Middle Aged Older people Polymorphism Polymorphism, Genetic Risk Factors |
| title | The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample |
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