Genome-wide transcriptional sequencing identifies novel mutations in metabolic genes in human hepatocellular carcinoma

We report on next-generation transcriptome sequencing results of three human hepatocellular carcinoma tumor/tumor-adjacent pairs. This analysis robustly examined ∼12,000 genes for both expression differences and molecular alterations. We observed 4,513 and 1,182 genes demonstrating 2-fold or greater...

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Veröffentlicht in:	Cancer genomics & proteomics 2014-01, Vol.11 (1), p.1-12
Hauptverfasser:	Meerzaman, Daoud M, Yan, Chunhua, Chen, Qing-Rong, Edmonson, Michael N, Schaefer, Carl F, Clifford, Robert J, Dunn, Barbara K, Dong, Li, Finney, Richard P, Cultraro, Constance M, Hu, Ying, Yang, Zhihui, Nguyen, Cu V, Kelley, Jenny M, Cai, Shuang, Zhang, Hongen, Zhang, Jinghui, Wilson, Rebecca, Messmer, Lauren, Chung, Young-Hwa, Kim, Jeong A, Park, Neung Hwa, Lyu, Myung-Soo, Song, Il Han, Komatsoulis, George, Buetow, Kenneth H
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism DNA Mutational Analysis DNA, Neoplasm - genetics Gene Expression Genome-Wide Association Study Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Mutation RNA, Neoplasm - genetics Transcriptome
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