Coalition of Nuclear Receptors in the Nervous System
A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post‐mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of F...
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| Veröffentlicht in: | Journal of cellular physiology 2015-12, Vol.230 (12), p.2875-2880 |
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| container_title | Journal of cellular physiology |
| container_volume | 230 |
| creator | Förthmann, Benjamin Aletta, John M. Lee, Yu-Wei Terranova, Chris Birkaya, Barbara Stachowiak, Ewa K. Stachowiak, Michal K. Claus, Peter |
| description | A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post‐mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non‐canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons. J. Cell. Physiol. 230: 2875–2880, 2015. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jcp.25036 |
| format | Article |
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Cell. Physiol</addtitle><description>A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post‐mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non‐canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons. J. Cell. Physiol. 230: 2875–2880, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>Dopaminergic Neurons - metabolism</subject><subject>Embryonic Stem Cells - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Humans</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Nervous System - cytology</subject><subject>Nervous System - metabolism</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neurogenesis</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism</subject><subject>Receptor Cross-Talk</subject><subject>Receptor, Fibroblast Growth Factor, Type 1 - metabolism</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Receptors, Cytoplasmic and Nuclear - metabolism</subject><subject>Signal Transduction</subject><subject>Stem cells</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LwzAYgIMobk4P_gEpeNFDt3ynPUrV6RhTNsVjaNIUO7t1Jq26f2_mPg6C4CmQPO_DmweAUwS7CELcm-pFFzNI-B5oIxiLkHKG90Hbv6EwZhS1wJFzUwhhHBNyCFqYxZxHiLUBTaq0LOqimgdVHowaXZrUBmOjzaKurAuKeVC_mmBk7EfVuGCydLWZHYODPC2dOdmcHfB8e_OU3IXDh_59cjUMNcWUhwpThbMYMWEgzRBSlHKqYK4w4zgyWlGEFROxzkREKM40zpm_TZFCURprQTrgYu1d2Oq9Ma6Ws8JpU5bp3PhtJBJI0JU_-gcKBWOMQO7R81_otGrs3H9kRXG_EBHIU5drStvKOWtyubDFLLVLiaBcVZe-uvyp7tmzjbFRM5PtyG1mD_TWwGdRmuXfJjlIHrfKcD1R-OBfu4nUvkkuiGDyZdSX48n1GI8HQibkG8wal90</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Förthmann, Benjamin</creator><creator>Aletta, John M.</creator><creator>Lee, Yu-Wei</creator><creator>Terranova, Chris</creator><creator>Birkaya, Barbara</creator><creator>Stachowiak, Ewa K.</creator><creator>Stachowiak, Michal K.</creator><creator>Claus, Peter</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Coalition of Nuclear Receptors in the Nervous System</title><author>Förthmann, Benjamin ; Aletta, John M. ; Lee, Yu-Wei ; Terranova, Chris ; Birkaya, Barbara ; Stachowiak, Ewa K. ; Stachowiak, Michal K. ; Claus, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4246-b24b2d9157e04d11b4464b0fb25628ecb412b579cd78342dc2f5ecba1b18a9c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Dopaminergic Neurons - metabolism</topic><topic>Embryonic Stem Cells - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humans</topic><topic>Nerve Growth Factor - metabolism</topic><topic>Nervous System - cytology</topic><topic>Nervous System - metabolism</topic><topic>Neural Stem Cells - metabolism</topic><topic>Neurogenesis</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism</topic><topic>Receptor Cross-Talk</topic><topic>Receptor, Fibroblast Growth Factor, Type 1 - metabolism</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Signal Transduction</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Förthmann, Benjamin</creatorcontrib><creatorcontrib>Aletta, John M.</creatorcontrib><creatorcontrib>Lee, Yu-Wei</creatorcontrib><creatorcontrib>Terranova, Chris</creatorcontrib><creatorcontrib>Birkaya, Barbara</creatorcontrib><creatorcontrib>Stachowiak, Ewa K.</creatorcontrib><creatorcontrib>Stachowiak, Michal K.</creatorcontrib><creatorcontrib>Claus, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Förthmann, Benjamin</au><au>Aletta, John M.</au><au>Lee, Yu-Wei</au><au>Terranova, Chris</au><au>Birkaya, Barbara</au><au>Stachowiak, Ewa K.</au><au>Stachowiak, Michal K.</au><au>Claus, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coalition of Nuclear Receptors in the Nervous System</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. Cell. Physiol</addtitle><date>2015-12</date><risdate>2015</risdate><volume>230</volume><issue>12</issue><spage>2875</spage><epage>2880</epage><pages>2875-2880</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post‐mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Dopaminergic Neurons - metabolism Embryonic Stem Cells - metabolism Gene Expression Regulation, Developmental Humans Nerve Growth Factor - metabolism Nervous System - cytology Nervous System - metabolism Neural Stem Cells - metabolism Neurogenesis Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism Receptor Cross-Talk Receptor, Fibroblast Growth Factor, Type 1 - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction Stem cells |
| title | Coalition of Nuclear Receptors in the Nervous System |
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