The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats
The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups ( n = 6 per group). Each group received 1 mL...
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| Veröffentlicht in: | Biological trace element research 2015-09, Vol.167 (1), p.110-114 |
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| creator | Su, Rongsheng Cao, Huabin Pan, Jiaqiang Li, Chengmei Chen, Yizhou Tang, Zhaoxin |
| description | The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (
n
= 6 per group). Each group received 1 mL (intragastrically) of water (control, group I) or water containing copper chloride (CuCl
2,
1 mol/L) (group II) or a mixture of CuCl
2
(1 mol/L) with sodium selenite (Na
2
SeO
3
, 0.05 mol/L) (group III) once daily for 30 days. Histological examination revealed normal hepatocyte structure and no ultrastructural changes in mitochondria in controls. In contrast, group II exhibited severe ultrastructural alterations, fuzzy mitochondrial membranes, irregularly shaped and fragmented rough endoplasmic reticulum (RER), and the high melanin content; group III also exhibited larger amounts of engulfing vesicles (EV) in the cytoplasm. Compared to controls, the CuCl
2
treatment lowered (
P
|
| doi_str_mv | 10.1007/s12011-015-0293-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1717490545</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1717490545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-f104f8c8522fd105459914226ad96921ca91ad9d3f640dface5a4741af52a8453</originalsourceid><addsrcrecordid>eNp1kUFrFDEUgIModlv9AV4k4MVLNC-bzEyOZalWqFTq9hxi8samzCZjkin26i9vlq0igqcE8r0vDz5CXgF_B5z37wsIDsA4KMaFXrPhCVmBUprxXvCnZMWhWzOpB3lEjku55Rz6hj0nR0L1nWiKFfm1vUH6JaeKroY7pFdpwkLTSL_ihDEsO5oiPcfZ1uDoNpSyIL2earal5sXVJSO10dPPoSZ3k6LPwU70NNaQfgZvY6UbO1sX6j0NkW7SPGNml3eYp2Q9enpla3lBno12Kvjy8Twh1x_OtptzdnH58dPm9II5yVVlI3A5Dm5QQoweuJJKa5BCdNbrTgtwVkO7-vXYSe5H61BZ2UuwoxJ2kGp9Qt4evHNOPxYs1exCcThNNmJaioEeeqn34oa--Qe9TUuObTsDnR76XsmBNwoOlMuplIyjmXPY2XxvgJt9IHMIZFogsw9khjbz-tG8fNuh_zPxu0gDxAEo7Sl-x_zX1_-1PgAgR5vR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1698775480</pqid></control><display><type>article</type><title>The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Su, Rongsheng ; Cao, Huabin ; Pan, Jiaqiang ; Li, Chengmei ; Chen, Yizhou ; Tang, Zhaoxin</creator><creatorcontrib>Su, Rongsheng ; Cao, Huabin ; Pan, Jiaqiang ; Li, Chengmei ; Chen, Yizhou ; Tang, Zhaoxin</creatorcontrib><description>The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (
n
= 6 per group). Each group received 1 mL (intragastrically) of water (control, group I) or water containing copper chloride (CuCl
2,
1 mol/L) (group II) or a mixture of CuCl
2
(1 mol/L) with sodium selenite (Na
2
SeO
3
, 0.05 mol/L) (group III) once daily for 30 days. Histological examination revealed normal hepatocyte structure and no ultrastructural changes in mitochondria in controls. In contrast, group II exhibited severe ultrastructural alterations, fuzzy mitochondrial membranes, irregularly shaped and fragmented rough endoplasmic reticulum (RER), and the high melanin content; group III also exhibited larger amounts of engulfing vesicles (EV) in the cytoplasm. Compared to controls, the CuCl
2
treatment lowered (
P
< 0.05) hepatocyte enzymatic activities and increased lipid peroxidation as indicated by an increase in malondialdehyde (MDA) levels. The effects of CuCl
2
were attenuated by simultaneous administration with Na
2
SeO
3
. These results indicated that the adverse effects of copper toxicity can be partially attenuated by providing a source of selenium.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-015-0293-8</identifier><identifier>PMID: 25762100</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Catalase - metabolism ; Copper ; Copper - pharmacology ; Enzymatic activity ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Hepatocytes - ultrastructure ; Hepatology ; Life Sciences ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Liver - ultrastructure ; Male ; Malondialdehyde - metabolism ; Melanins - metabolism ; Microscopy, Electron, Transmission ; Mitochondria ; Mitochondria, Liver - drug effects ; Mitochondria, Liver - metabolism ; Mitochondria, Liver - ultrastructure ; Nutrition ; Oncology ; Peroxidation ; Protective Agents - pharmacology ; Rats, Sprague-Dawley ; Rodents ; Selenium ; Selenium - pharmacology ; Sodium Selenite - pharmacology ; Superoxide Dismutase - metabolism ; Tissues</subject><ispartof>Biological trace element research, 2015-09, Vol.167 (1), p.110-114</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-f104f8c8522fd105459914226ad96921ca91ad9d3f640dface5a4741af52a8453</citedby><cites>FETCH-LOGICAL-c405t-f104f8c8522fd105459914226ad96921ca91ad9d3f640dface5a4741af52a8453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-015-0293-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-015-0293-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25762100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Rongsheng</creatorcontrib><creatorcontrib>Cao, Huabin</creatorcontrib><creatorcontrib>Pan, Jiaqiang</creatorcontrib><creatorcontrib>Li, Chengmei</creatorcontrib><creatorcontrib>Chen, Yizhou</creatorcontrib><creatorcontrib>Tang, Zhaoxin</creatorcontrib><title>The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (
n
= 6 per group). Each group received 1 mL (intragastrically) of water (control, group I) or water containing copper chloride (CuCl
2,
1 mol/L) (group II) or a mixture of CuCl
2
(1 mol/L) with sodium selenite (Na
2
SeO
3
, 0.05 mol/L) (group III) once daily for 30 days. Histological examination revealed normal hepatocyte structure and no ultrastructural changes in mitochondria in controls. In contrast, group II exhibited severe ultrastructural alterations, fuzzy mitochondrial membranes, irregularly shaped and fragmented rough endoplasmic reticulum (RER), and the high melanin content; group III also exhibited larger amounts of engulfing vesicles (EV) in the cytoplasm. Compared to controls, the CuCl
2
treatment lowered (
P
< 0.05) hepatocyte enzymatic activities and increased lipid peroxidation as indicated by an increase in malondialdehyde (MDA) levels. The effects of CuCl
2
were attenuated by simultaneous administration with Na
2
SeO
3
. These results indicated that the adverse effects of copper toxicity can be partially attenuated by providing a source of selenium.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Catalase - metabolism</subject><subject>Copper</subject><subject>Copper - pharmacology</subject><subject>Enzymatic activity</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Hepatocytes - ultrastructure</subject><subject>Hepatology</subject><subject>Life Sciences</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Melanins - metabolism</subject><subject>Microscopy, Electron, Transmission</subject><subject>Mitochondria</subject><subject>Mitochondria, Liver - drug effects</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Mitochondria, Liver - ultrastructure</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Peroxidation</subject><subject>Protective Agents - pharmacology</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Selenium</subject><subject>Selenium - pharmacology</subject><subject>Sodium Selenite - pharmacology</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tissues</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFrFDEUgIModlv9AV4k4MVLNC-bzEyOZalWqFTq9hxi8samzCZjkin26i9vlq0igqcE8r0vDz5CXgF_B5z37wsIDsA4KMaFXrPhCVmBUprxXvCnZMWhWzOpB3lEjku55Rz6hj0nR0L1nWiKFfm1vUH6JaeKroY7pFdpwkLTSL_ihDEsO5oiPcfZ1uDoNpSyIL2earal5sXVJSO10dPPoSZ3k6LPwU70NNaQfgZvY6UbO1sX6j0NkW7SPGNml3eYp2Q9enpla3lBno12Kvjy8Twh1x_OtptzdnH58dPm9II5yVVlI3A5Dm5QQoweuJJKa5BCdNbrTgtwVkO7-vXYSe5H61BZ2UuwoxJ2kGp9Qt4evHNOPxYs1exCcThNNmJaioEeeqn34oa--Qe9TUuObTsDnR76XsmBNwoOlMuplIyjmXPY2XxvgJt9IHMIZFogsw9khjbz-tG8fNuh_zPxu0gDxAEo7Sl-x_zX1_-1PgAgR5vR</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Su, Rongsheng</creator><creator>Cao, Huabin</creator><creator>Pan, Jiaqiang</creator><creator>Li, Chengmei</creator><creator>Chen, Yizhou</creator><creator>Tang, Zhaoxin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20150901</creationdate><title>The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats</title><author>Su, Rongsheng ; Cao, Huabin ; Pan, Jiaqiang ; Li, Chengmei ; Chen, Yizhou ; Tang, Zhaoxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f104f8c8522fd105459914226ad96921ca91ad9d3f640dface5a4741af52a8453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Catalase - metabolism</topic><topic>Copper</topic><topic>Copper - pharmacology</topic><topic>Enzymatic activity</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Hepatocytes - ultrastructure</topic><topic>Hepatology</topic><topic>Life Sciences</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Melanins - metabolism</topic><topic>Microscopy, Electron, Transmission</topic><topic>Mitochondria</topic><topic>Mitochondria, Liver - drug effects</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Mitochondria, Liver - ultrastructure</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Peroxidation</topic><topic>Protective Agents - pharmacology</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Selenium</topic><topic>Selenium - pharmacology</topic><topic>Sodium Selenite - pharmacology</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Rongsheng</creatorcontrib><creatorcontrib>Cao, Huabin</creatorcontrib><creatorcontrib>Pan, Jiaqiang</creatorcontrib><creatorcontrib>Li, Chengmei</creatorcontrib><creatorcontrib>Chen, Yizhou</creatorcontrib><creatorcontrib>Tang, Zhaoxin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Rongsheng</au><au>Cao, Huabin</au><au>Pan, Jiaqiang</au><au>Li, Chengmei</au><au>Chen, Yizhou</au><au>Tang, Zhaoxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>167</volume><issue>1</issue><spage>110</spage><epage>114</epage><pages>110-114</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (
n
= 6 per group). Each group received 1 mL (intragastrically) of water (control, group I) or water containing copper chloride (CuCl
2,
1 mol/L) (group II) or a mixture of CuCl
2
(1 mol/L) with sodium selenite (Na
2
SeO
3
, 0.05 mol/L) (group III) once daily for 30 days. Histological examination revealed normal hepatocyte structure and no ultrastructural changes in mitochondria in controls. In contrast, group II exhibited severe ultrastructural alterations, fuzzy mitochondrial membranes, irregularly shaped and fragmented rough endoplasmic reticulum (RER), and the high melanin content; group III also exhibited larger amounts of engulfing vesicles (EV) in the cytoplasm. Compared to controls, the CuCl
2
treatment lowered (
P
< 0.05) hepatocyte enzymatic activities and increased lipid peroxidation as indicated by an increase in malondialdehyde (MDA) levels. The effects of CuCl
2
were attenuated by simultaneous administration with Na
2
SeO
3
. These results indicated that the adverse effects of copper toxicity can be partially attenuated by providing a source of selenium.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25762100</pmid><doi>10.1007/s12011-015-0293-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biological trace element research, 2015-09, Vol.167 (1), p.110-114 |
| issn | 0163-4984 1559-0720 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antioxidants Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biotechnology Catalase - metabolism Copper Copper - pharmacology Enzymatic activity Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - ultrastructure Hepatology Life Sciences Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Liver - ultrastructure Male Malondialdehyde - metabolism Melanins - metabolism Microscopy, Electron, Transmission Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - ultrastructure Nutrition Oncology Peroxidation Protective Agents - pharmacology Rats, Sprague-Dawley Rodents Selenium Selenium - pharmacology Sodium Selenite - pharmacology Superoxide Dismutase - metabolism Tissues |
| title | The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats |
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