Handgrip Exercise Training Following Transradial Catheterization Ameliorates Arterial Dysfunction

The aim of the present study was to assess radial artery vasodilator function prior to transradial catheterization and again following randomisation to 6 weeks of rehabilitative localized handgrip training or a similar inactive control period. Twenty-five subjects undergoing transradial catheterization were recruited and assessed before (Pre) and 6 weeks following (Post) catheterization. Subjects were randomized to either 6 weeks of handgrip exercise training (Exercise, n=14) or a similar non-exercise group (Control, n=11). FMD was significantly impaired following catheterisation in the Control group (7.9+ or -1.4 to 4.5+ or -0.6%), but was maintained in the Exercise group (6.0+ or -0.9 to 6.6+ or -0.9%; pre versus post) (P0.05). There were no significant differences between the groups or across time for either the ACh or the SNP protocols (P>0.05). Post-hoc t-tests in the Exercise group showed a significant increase from baseline blood flows with all SNP infusions (P